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Role of Drug – Drug Interactions in the Efficacy and Safety of Clarithromycin Treatment for Helicobacter Pylori Eradication

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Pharmaceutical Chemistry Journal Aims and scope

Current risks from resistance, adverse drug reactions, and drug – drug interactions of clarithromycin used as a component of Helicobacter pylori eradication therapy are reviewed. The acid sensitivity of clarithromycin i responsible for the dependence of its pharmacological properties on the efficacy of proton-pump inhibitors, which could be one reason for the resistance of H. pylori to the macrolide. The potential for clarithromycin drug – drug interactions is related to its metabolism by CYP3A4 and strong inhibition of this enzyme.

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Acknowledgments

The work was performed in the framework of a state task for SCEEMP, Ministry of Health of Russia, No. 056-00154-19-00.

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Authors and Affiliations

  1. Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051, Russia

    S. Yu. Serebrova, N. N. Eremenko & A. B. Prokof’ev

  2. I. M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia

    S. Yu. Serebrova, E. N. Kareva, N. N. Eremenko, A. B. Prokof’ev, D. O. Kurguzova, V. N. Drozdov, N. B. Lazareva & A. K. Starodubtsev

  3. N. I. Pirogov National Research Medical University, 1 Ostrovityanova St., Moscow, 117997, Russia

    E. N. Kareva

  4. A. I. Evdokimov Moscow State University of Medicine and Dentistry, 20/1 Delegatskaya St., Moscow, 127473, Russia

    I. A. Komissarenko

Authors
  1. S. Yu. Serebrova
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  2. E. N. Kareva
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  3. N. N. Eremenko
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  4. A. B. Prokof’ev
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  5. D. O. Kurguzova
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  6. V. N. Drozdov
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  7. N. B. Lazareva
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  8. I. A. Komissarenko
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  9. A. K. Starodubtsev
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Corresponding author

Correspondence to E. N. Kareva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 8, pp. 8 – 10, August, 2019.

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Serebrova, S.Y., Kareva, E.N., Eremenko, N.N. et al. Role of Drug – Drug Interactions in the Efficacy and Safety of Clarithromycin Treatment for Helicobacter Pylori Eradication. Pharm Chem J 53, 678–679 (2019). https://doi.org/10.1007/s11094-019-02061-5

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  • DOI: https://doi.org/10.1007/s11094-019-02061-5

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