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Synthesis and antimicrobial activity of mono-and biquaternized derivatives of dipyridylethanes and dipyridylethylenes

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Abstract

A series of mono-and biquaternized derivatives of dipyridylethanes and dipyridylethylenes has been synthesized and characterized with respect to antimicrobial activity. The new compounds exhibit structure-dependent antimicrobial action on both Gram-negative (E. coli) and Gram-positive (St. aureus) bacterial species. Monoquaternized dipyridylethane and dipyridylethylene derivatives show a higher antimicrobial activity than compounds with two onium nitrogen atoms; derivatives of dipyridylethane are less active than the analogous derivatives of dipyridylethylene. A high antimicrobial activity (MIC ∼ 1 mg/ml) was observed for 1-[N-cetyl-(4-pyridinium)]-2-(4-pyridyl)ethylene.

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Authors and Affiliations

  1. Institute of Technical Chemistry, Ural Division, Russian Academy of Sciences, Perm, Russia

    Zh. A. Vnutskikh, Yu. V. Shklyaev, Yu. S. Chekryshkin, A. G. Tolstikov & N. V. El’chishcheva

  2. Perm State Pharmaceutical Academy, Perm, Russia

    T. F. Odegova & B. Ya. Syropyatov

Authors
  1. Zh. A. Vnutskikh
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  2. Yu. V. Shklyaev
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  3. T. F. Odegova
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  4. Yu. S. Chekryshkin
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  5. A. G. Tolstikov
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  6. N. V. El’chishcheva
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  7. B. Ya. Syropyatov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 4, pp. 19–22, April, 2006.

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Vnutskikh, Z.A., Shklyaev, Y.V., Odegova, T.F. et al. Synthesis and antimicrobial activity of mono-and biquaternized derivatives of dipyridylethanes and dipyridylethylenes. Pharm Chem J 40, 194–198 (2006). https://doi.org/10.1007/s11094-006-0090-y

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  • DOI: https://doi.org/10.1007/s11094-006-0090-y

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