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High performance biosensor composed of 1D defective photonic crystal for sensing and detection of distinguished blood components

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Abstract

In the present research work, one-dimensional defective photonic structure based blood sensor is worked out proposed for accurate sensing and detection of the ten most important components of human blood like cytop, blood plasma, WBCs, HB, RBCs, syogard-184, biotin–streptavidin, polyacrylamide, bovine serum albumin, and UMD. This design utilizes a 1D defective photonic crystal composed of materials PbS and MgF2 with an uncoated central defect layer of air. The method transfer matrix has been applied to obtain theoretical results of the present work in addition to MATLAB software. The uncoated central defect layer of air has been infiltrated with various blood samples one by one to get the response of the present biosensor. The keystone of the work is to study the movement of resonant mode position in the photonic band gap due to variation in the index of refraction of human blood samples poured into the cavity region of the biosensor. The process of optimizing the geometrical parameters of the present biosensing structure like cavity region thickness, incident angle and period number has been discussed for making our design most sensitive. The sensing and detection capabilities of the structure have been examined by evaluating various biosensing parameters like sensitivity, limit of detection, quality factor and figure of merit with the help of transmission spectra of the design. Additionally, the results of the present biosensing work are also compared with the earlier photonic blood sensing related research work to highlight the novelty of this manuscript. The fabrication of the present design can easily be realized by using any one of the modern multilayer thin film deposition techniques. The architecture of the present biosensor is simple and cost-effective in contrast to the challenges involved in the fabrication of 2D and 3D photonic biosensors.

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The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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No code is used in this study.

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Acknowledgements

The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through large Groups Project under Grant Number RGP. 2/38/43

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Authors and Affiliations

  1. TH-PPM Group, Physics Department, Faculty of Sciences, Beni-Suef University, Beni Suef, 62514, Egypt

    C. Malek, W. Sabra & Arafa H. Aly

  2. Department of Physics, Faculty of Science, King Khalid University, 62529, Abha, Kingdom of Saudi Arabia

    M. Al-Dossari

  3. Department of Physics and Material Science and Engineering, Jaypee Institute of Information Technology, Noida, 201304, India

    S. K. Awasthi

  4. Physics Department, University College in Al Arda, Jazan University, 82817, Jazan, Kingdom of Saudi Arabia

    M. A. Ismail

  5. Faculty of Technology and Education, Beni-Suef University, Beni Suef, 62521, Egypt

    M. A. Ismail

  6. Faculty of Sciences, King Khalid University, 61421, Mohayel Asser, Abha, Kingdom of Saudi Arabia

    N. S. Abd El-Gawaad

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  1. C. Malek
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Malek, C., Al-Dossari, M., Awasthi, S.K. et al. High performance biosensor composed of 1D defective photonic crystal for sensing and detection of distinguished blood components. Opt Quant Electron 55, 196 (2023). https://doi.org/10.1007/s11082-022-04460-7

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