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Diffuse optical imaging through incorporating structural information into edge-preserving regularization

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Abstract

Diffuse optical imaging (DOI) is emerging as a new functional imaging modality that can be used for breast cancer screening. Due to the ill-posed inverse problem for DOI image reconstruction, regularization is essential to remedy such a drawback. In our previous study, we have successfully implemented edge-preserving regularization into image reconstruction algorithm for improving the reconstructed images. In this study, we incorporate additional anatomical image, which can be obtained from other imaging modality such as mammography or magnetic resonance imaging, although showing no tumor information, into edge-preserving regularization for further improving the reconstructed images. Reconstruction results show that the quality of reconstructed images can be significantly improved.

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References

  • Azar, F.S., Lee, K., Khamene, A., Choe, R., Corlu, A., Konecky, S.D., Sauer, F., Yodh, A.G.: Standardized platform for coregistration of nonconcurrent diffuse optical and magnetic resonance breast images obtained in different geometries. J. Biomed. Opt. 12, 051902 (2007)

    Article  ADS  Google Scholar 

  • Boverman, G., Miller, E.L., Li, A., Zhang, Q., Chaves, T., Brooks, D.H., Boas, D.A.: Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information. Phys. Med. Biol. 50, 3941–3956 (2005)

    Article  Google Scholar 

  • Brooksby, B., Jiang, S., Dehghani, H., Pogue, B.W., Paulsen, K.D., Kogel, C., Doyley, M., Weaver, J.B., Poplack, S.P.: Magnetic resonance-guided near-infrared tomography of the breast. Rev. Sci. Instrum. 75, 5262–5270 (2004)

    Article  ADS  Google Scholar 

  • Brooksby, B., Jiang, S., Dehghani, H., Pogue, B.W., Paulsen, K.D., Weaver, J., Kogel, C., Poplack, S.P.: Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure. J. Biomed. Opt. 10, 051504 (2005)

    Article  ADS  Google Scholar 

  • Brooksby, B., Pogue, B.W., Jiang, S., Dehghani, H., Srinivasan, S., Kogel, C., Tosteson, T.D., Weaver, J., Poplack, S.P., Paulsen, K.D.: Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography. Proc. Natl. Acad. Sci. U.S.A. 103, 8828–8833 (2006)

    Article  ADS  Google Scholar 

  • Cerussi, A., Shah, N., Hsiang, D., Durkin, A., Butler, J., Tromberg, B.J.: In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy. J. Biomed. Opt. 11, 044005 (2006)

    Article  ADS  Google Scholar 

  • Chen, N.G., Guo, P., Yan, S., Piao, D., Zhu, Q.: Simultaneous near-infrared diffusive light and ultrasound imaging. Appl. Opt. 40, 6367–6380 (2001)

    Article  ADS  Google Scholar 

  • Chen, L.Y., Pan, M.C., Pan, M.C.: Implementation of edge-preserving regularization for frequency-domain diffuse optical tomography. Appl. Opt. 51, 43–54 (2012)

    Article  ADS  Google Scholar 

  • Chen, L.Y., Pan, M.C., Pan, M.C.: Flexible near-infrared diffuse optical tomography with varied weighting functions of edge-preserving regularization. Appl. Opt. 52, 1173–1182 (2013)

    Article  ADS  Google Scholar 

  • Choe, R., Konecky, S.D., Corlu, A., Lee, K., Durduran, T., Busch, D.R., Pathak, S., Czerniecki, B.J., Tchou, J., Fraker, D.L., DeMichele, A., Chance, B., Arridge, S.R., Schweiger, M., Culver, J.P., Schnall, M.D., Putt, M.E., Rosen, M.A., Yodh, A.G.: Differentiation of benign and malignant breast tumors by in vivo three-dimensional parallel-plate diffuse optical tomography. J. Biomed. Opt. 14, 024020 (2009)

    Article  ADS  Google Scholar 

  • Collettini, F., Martin, J.C., Diekmann, F., Fallenberg, E., Engelken, F., Ponder, S., Kroencke, T.J., Hamm, B., Poellinger, A.: Diagnostic performance of a near-infrared breast imaging system as adjunct to mammography versus X-ray mammography alone. Eur. Radiol. 22, 350–357 (2012)

    Article  Google Scholar 

  • Durduran, T., Choe, R., Baker, W.B., Yodh, A.G.: Diffuse optics for tissue monitoring and tomography. Rep. Prog. Phys. 73, 076701 (2012)

    Article  ADS  Google Scholar 

  • Elmore, J.G., Barton, M.B., Moceri, V.M., Polk, S., Arena, P.J., Fletcher, S.W.: Ten-year risk of false positive screening mammograms and clinical breast examinations. N. Engl. J. Med. 338, 1089–1096 (1998)

    Article  Google Scholar 

  • Fang, Q., Carp, S.A., Selb, J., Boverman, G., Zhang, Q., Kopans, D.B., Moore, R.H., Miller, E.L., Brooks, D.H., Boas, D.A.: Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression. IEEE Trans. Med. Imaging 28, 30–42 (2009)

    Article  Google Scholar 

  • Fang, Q., Selb, J., Carp, S.A., Boverman, G., Miller, E.L., Brooks, D.H., Moore, R.H., Kopans, D.B., Boas, D.A.: Combinded optical and X-ray tomosynthesis breast imaging. Radiology 258, 89–97 (2011)

    Article  Google Scholar 

  • Fantini, S., Sassaroli, A.: Near-infrared optical mammography for breast cancer detection with intrinsic contrast. Ann. Biomed. Eng. 40, 398–407 (2012)

    Article  Google Scholar 

  • Huynh, P.T., Jarolimek, A.M., Day, S.: The false-negative mammogram. Radiographics 18, 1137–1154 (1998)

    Article  Google Scholar 

  • Hylton, N.: Magnetic resonance imaging of the breast: opportunities to improve breast cancer management. J. Clin. Oncol. 23, 1678–1684 (2005)

    Article  Google Scholar 

  • Kolb, T.M., Lichy, J., Newhouse, J.H.: Comparison of the performance of screening mammography, physical examination and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations. Radiology 225, 165–175 (2002)

    Article  Google Scholar 

  • Krishnaswamy, V., Michaelsen, K.E., Pogue, B.W., Poplack, S.P., Shaw, I., Defrietas, K., Brooks, K., Paulsen, K.D.: A digital X-ray tomosynthesis coupled near-infrared spectral tomography system for dual-modality breast imaging. Opt. Express 20, 19125–19136 (2012)

    Article  ADS  Google Scholar 

  • Li, A., Miller, E.L., Kilmer, M.E., Brukilacchio, T.J., Chaves, T., Stott, J., Zhang, Q., Wu, T., Chorlton, M., Moore, R.H., Kopans, D.B., Boas, D.A.: Tomographic optical breast imaging guided by three-dimensional mammography. Appl. Opt. 42, 5181–5190 (2003)

    Article  ADS  Google Scholar 

  • Michaelsen, K., Krishnaswamy, V., Pogue, B.W., Poplack, S.P., Paulsen, K.D.: Near-infrared spectral tomography integrated with digital breast tomosynthesis: effects of tissue scattering on optical data acquisition design. Med. Phys. 39, 4579–4587 (2012)

    Article  Google Scholar 

  • Nothacker, M., Duda, V., Hahn, M., Warm, M., Degenhardt, F., Madjar, H., Weinbrenner, S., Albert, U.-S.: Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue. A systematic review. BMC Cancer 9, 335 (2009)

    Article  Google Scholar 

  • Tabar, L., Yen, M.F., Vitak, B., Chen, H.T., Smith, R.A., Duffy, S.W.: Mammography service screening and mortality in breast cancer patients: 20-year follow-up before and after introduction of screening. Lancet 361, 1405–1410 (2003)

    Article  Google Scholar 

  • World Health Organization. Cancer Fact Sheet No. 297. Technical report (2015)

  • Yalavarthy, P.K., Pogue, B.W., Dehghani, H., Carpenter, C.M., Jiang, S., Paulsen, K.D.: Structural information within regularization matrices improves near infrared diffuse optical tomography. Opt. Express 15, 8043–8058 (2007)

    Article  ADS  Google Scholar 

  • Zhao, Y., Mastanduno, M.A., Jiang, S., Ghussein, F., Gui, J., Pogue, B.W., Paulsen, K.D.: Optimization of image reconstruction for magnetic resonance imaging-guided near-infrared diffuse optical spectroscopy in breast. J. Biomed. Opt. 20, 056009 (2015)

    Article  ADS  Google Scholar 

  • Zhu, Q., Chen, N.G.: Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound. Opt. Lett. 28, 337–339 (2003)

    Article  ADS  Google Scholar 

  • Zhu, Q., Durdurna, T., Ntziachristos, V., Holboke, M., Yodh, A.G.: Imager that combines near-infrared diffusive light and ultrasound. Opt. Lett. 24, 1050–1052 (1999)

    Article  ADS  Google Scholar 

  • Zhu, Q., Tannenbaum, S., Hegde, P., Kane, M., Xu, C., Kurtzman, S.H.: Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization. Neoplasia 10, 1028–1040 (2008)

    Article  Google Scholar 

Download references

Acknowledgments

This research was financially supported by the Ministry of Science and Technology in Taiwan through Grants 101-2221-E-008-010-MY2, 101-2221-E-008-093-MY3, and 101-2221-E-236-014.

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Authors and Affiliations

  1. Graduate Institute of Biomedical Engineering, National Central University, No. 300, Jhongda Rd., Jhongli District, Taoyuan City, 32001, Taiwan, R.O.C.

    Liang-Yu Chen & Min-Chun Pan

  2. Department of Mechanical Engineering, National Central University, No. 300, Jhongda Rd., Jhongli District, Taoyuan City, 32001, Taiwan, R.O.C.

    Liang-Yu Chen, Jhao-Ming Yu & Min-Chun Pan

  3. Department of Electronic Engineering, Tung-Nan University, No. 152, Sec. 3, Beishen Rd., Shenkeng District, New Taipei City, 222, Taiwan, R.O.C.

    Min-Cheng Pan

Authors
  1. Liang-Yu Chen
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  2. Min-Cheng Pan
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  3. Jhao-Ming Yu
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Correspondence to Min-Chun Pan.

Additional information

This article is part of the Topical Collection on Micro/Nano Photonics for the International Year of Light 2015.

Guest Edited by Yen-Hsun Su, Lei Liu, Xinlong Xu and Zhenhua Ni.

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Chen, LY., Pan, MC., Yu, JM. et al. Diffuse optical imaging through incorporating structural information into edge-preserving regularization. Opt Quant Electron 48, 130 (2016). https://doi.org/10.1007/s11082-015-0365-1

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