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Association Between Alzheimer Disease and the −491T Allele of Regulatory Region Polymorphism of Apolipoprotein E in a Tunisian Population

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Abstract

The apolipoprotein E (APOE) is a well-established risk factor for late-onset Alzheimer’s disease (AD). Several studies have attempted to confirm the association between the polymorphism located at position −491 in the transcriptional regulatory region of the APOE gene and AD. We examined in 85 AD patients and 90 control subjects of a Tunisian population the potential involvement of this polymorphism as a risk factor for AD, either through an independent effect or through interaction with the existing APOE ε4 allele risk. The T allele frequency was significantly higher in the AD patients group (45.3 %) than in the controls group (32.78 %) and may possibly constitute a significant risk factor for AD. The APOE ε4 allele did not influence the distribution of the −491 polymorphism after stratification.

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Acknowledgments

This work was funded by the Ministry of Higher Education and Scientific Research in Tunisia.

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Authors and Affiliations

  1. Neurological Department, Charles Nicolle Hospital, Boulevard du 9 Avril, 1006, Tunis, Tunisia

    Afef Achouri-Rassas, Hela Mrabet Khiari & Amel Mrabet

  2. Biochemistry and Molecular Biology Laboratory, Children’s Hospital, Bab Saadoun, 1029, Tunis, Tunisia

    Afef Achouri-Rassas, Sondes Hadj Fredj, Amina Bibi, Hajer Siala & Taieb Messaoud

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  1. Afef Achouri-Rassas
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  2. Sondes Hadj Fredj
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  3. Hela Mrabet Khiari
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  6. Amel Mrabet
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Correspondence to Afef Achouri-Rassas.

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Achouri-Rassas, A., Hadj Fredj, S., Mrabet Khiari, H. et al. Association Between Alzheimer Disease and the −491T Allele of Regulatory Region Polymorphism of Apolipoprotein E in a Tunisian Population. Neurochem Res 39, 244–247 (2014). https://doi.org/10.1007/s11064-013-1213-y

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  • DOI: https://doi.org/10.1007/s11064-013-1213-y

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