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The Fruits of Maclura pomifera Extracts Inhibits Glioma Stem-Like Cell Growth and Invasion

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Abstract

Glioma is the most common primary intracranial tumour. Recently, growing evidence showed that glioma possesses stem-like cells, which are thought to be chemo- and radio-resistant and believed to contribute to the poor clinical outcomes of these tumours. In this study, we found that stem-like glioma cells (CD133+) were significantly increased in neurosphere cells, which are highly invasive and resistant to multiple chemotherapeutic agents. From our natural products library, we screened 48 natural products and found one compound, Pomiferin, which was of particular interest. Our results showed that Pomiferin could inhibit cell viability, CD133+ cell population, sphere formation, and invasion ability of glioma neurosphere cells. We also found that multiple stemness-associated genes (BIM1, Nestin, and Nanog) were down-regulated by Pomiferin treatment of glioma neurosphere cells. Taken together, our results suggest that Pomiferin could kill the cancer stem-like cells in glioma and may serve as a potential therapeutic agent in the future.

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Acknowledgments

This study was supported by Grants from the National Natural Science Foundation of China; Grant Number: 81201994.

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Authors and Affiliations

  1. Department of Neurosurgery, Zhangjiagang Hospital, Suzhou University, Zhangjiagang, 215600, China

    Dan Zhao, Li Zhang & Huixiang Liu

  2. Department of Radiation, Jiangsu Cancer Hospital, Nanjing, 210000, China

    Chengyun Yao

  3. Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, Henan Province, China

    Xiaobing Chen

  4. Department of Surgery, Yijishan Hospital, Wannan Medical College, Wuhu, 241001, China

    Hongping Xia, Xiaochun Jiang & Yi Dai

  5. Department of Neurosurgery, Ma’an Shan Central Hospital, Wannan Medical College, Ma’an Shan, 243000, China

    Jun Liu

Authors
  1. Dan Zhao
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  2. Chengyun Yao
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  3. Xiaobing Chen
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  4. Hongping Xia
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  5. Li Zhang
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  6. Huixiang Liu
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  7. Xiaochun Jiang
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  8. Yi Dai
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  9. Jun Liu
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Corresponding authors

Correspondence to Xiaobing Chen or Hongping Xia.

Additional information

Dan Zhao and Chengyun Yao have contributed equally to this work.

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Zhao, D., Yao, C., Chen, X. et al. The Fruits of Maclura pomifera Extracts Inhibits Glioma Stem-Like Cell Growth and Invasion. Neurochem Res 38, 2105–2113 (2013). https://doi.org/10.1007/s11064-013-1119-8

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  • DOI: https://doi.org/10.1007/s11064-013-1119-8

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