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Caffeic Acid Phenethyl Ester Exerts a Neuroprotective Effect on CNS Against Pentylenetetrazol-Induced Seizures in Mice

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Abstract

Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.

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Authors and Affiliations

  1. Departments of Neurology, Medical Faculty, Inonu University, Malatya, Turkey

    Atilla Ilhan

  2. Medical Faculty, Departments of Pharmacology, Inonu University, Malatya, Turkey

    Mustafa Iraz

  3. Medical Faculty, Department of Biochemistry, Karaelmas University , Zonguldak, Turkey

    Ahmet Gurel

  4. Medical Faculty, Departments of Biochemistry, Inonu University, Malatya, Turkey

    Ferah Armutcu

  5. Medical Faculty, Department of Neurology, Turgut Ozal Medical Center, Inonu University, 44069, Malatya, Turkey

    Atilla Ilhan & Omer Akyol

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  1. Atilla Ilhan
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  2. Mustafa Iraz
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  3. Ahmet Gurel
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  4. Ferah Armutcu
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  5. Omer Akyol
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Correspondence to Atilla Ilhan.

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Ilhan, A., Iraz, M., Gurel, A. et al. Caffeic Acid Phenethyl Ester Exerts a Neuroprotective Effect on CNS Against Pentylenetetrazol-Induced Seizures in Mice. Neurochem Res 29, 2287–2292 (2004). https://doi.org/10.1007/s11064-004-7038-y

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