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Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy

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Neurophysiology Aims and scope

We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by α ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.

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References

  1. D. Häussinger, “Hepatic encephalopathy,” Acta Gastroenterol. Belg., 73, No. 4, 457–464 (2010).

    PubMed  Google Scholar 

  2. S. Bengmark, “Bio-ecological control of chronic liver disease and encephalopathy,” Met. Brain Dis., 24, No. 1, 223–236 (2009).

    Article  Google Scholar 

  3. M. J. McPhail and S. D. Taylor-Robinson, “The role of magnetic resonance imaging and spectroscopy in hepatic encephalopathy,” Met. Brain Dis., 25, No. 1, 65–72 (2010).

    Article  Google Scholar 

  4. A. Lemberg and M. A. Fernández, “Hepatic encephalopathy, ammonia, glutamate, glutamine and oxidative stress,” Ann. Hepatol., 8, No. 2, 95–102 (2009).

    PubMed  Google Scholar 

  5. Patent 15752 of Ukraine, MPK G 09 B 23/28, A Technique of Modeling Chronic Hepatitis C, V. Yu. Nikolenko, Yu. I. Nikolenko, and O. Yu. Nikolenko; declarant and owner Donetsk State Medical University, No. u2006004614, publ. 17.07.2006/

  6. G. Ushakova, O. Fed’kiv, O. Prykhod’ko, et al., “The effect of long-term lactobacilli (lactic acid bacteria) enteral treatment on the central nervous system of growing rats,” J. Nutr. Biochem., 20, No. 9, 677–684 (2009).

    Article  PubMed  CAS  Google Scholar 

  7. J. Bureš, O. Burešova, D. P. Hewston, Methods And Main Experiments for Studying the Brain and Behavior [Russian translation], Vysshaya Shkola, Moscow (1991).

    Google Scholar 

  8. J. Steiner, B. Bogerts, M. L. Schroeter, et al., “S100B protein in neurodegenerative disorders,” Clin. Chem. Lab. Med., 49, No. 3, 409–424 (2011).

    Article  PubMed  CAS  Google Scholar 

  9. L. H. Brennaman and P. F. Maness, “NCAM in neuropsychiatric and neurodegenerative disorders,” Adv. Exp. Med. Biol., 663, 299–317 (2010).

    Article  PubMed  CAS  Google Scholar 

  10. R. Donato, G. Sorci, F. Riuzzi, et al., “S100B’s double life: intracellular regulator and extracellular signal,” Biochim. Biophys. Acta., 1793, No. 6, 1008–1022 (2009).

    Article  PubMed  CAS  Google Scholar 

  11. G. Ushakova, O. Fomenko, and S. Pierzynowski, “Noninvasive markers of hepatic encephalopathy under chronic hepatitis C and 2-oxoglutarate treatment,” Ann. Univ. Mariae Curie-Skladowska, Sectio DDD Pharm., 23, No. 3, 203–206 (2010).

    Google Scholar 

  12. A. Dityatev, O. Bukalo, and M. Schachner, “Modulation of synaptic transmission and plasticity by cell adhesion and repulsion molecules,” Neuron Glia Biol., 4, No. 3, 197-209 (2008).

    Article  PubMed  Google Scholar 

  13. R. Bisaz, L. Conboy, and C. Sandi, “Learning under stress: a role for the neural cell adhesion molecule NCAM,” Neurobiol. Learn. Mem., 91, No. 4, 333–342 (2009).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Oles’ Gonchar Dnipropetrovsk National University, Dnipropetrovsk, Ukraine

    G. A. Ushakova & O. Z. Fomenko

  2. Lund University, Lund, Sweden

    S. G. Pierzynowski

  3. Institute of Agricultural Medicine, Lyublin, Poland

    S. G. Pierzynowski

Authors
  1. G. A. Ushakova
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  2. O. Z. Fomenko
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  3. S. G. Pierzynowski
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Corresponding author

Correspondence to G. A. Ushakova.

Additional information

Neirofiziologiya/Neurophysiology, Vol. 43, No. 3, pp. 235–238, May-June, 2011.

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Ushakova, G.A., Fomenko, O.Z. & Pierzynowski, S.G. Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy. Neurophysiology 43, 205–208 (2011). https://doi.org/10.1007/s11062-011-9206-4

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  • DOI: https://doi.org/10.1007/s11062-011-9206-4

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