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Risk of post-operative venous thromboembolism in patients with meningioma

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Abstract

The surgical resection of meningiomas can be complicated by venous thromboembolism (VTE) in the post-operative period, but the exact incidence of this event is not known. Aim of this study was to assess the occurrence of VTE in patients operated for meningioma who underwent a post-operative clinical and objective screening for VTE. Patients undergoing meningioma resection between 2000 and 2010 who accepted to be investigated for VTE in the post-operative period were included in the study. The screening included daily clinical assessment, pulmonary perfusion scintigraphy (Q-SCAN) on day 2 and venous compression ultrasonography (CUS) of the lower limbs within day 7. The univariate and multivariate statistical analysis of risk factors for VTE included sex, age, presence of comorbidities, pre- and post-operative Karnofsky Performance scale (KPS), post-operative neurological worsening and post-operative walking ability. Two-hundred and seventy-five patients were included in the study. VTE was diagnosed in 82 patients (29.8%). Univariate analysis revealed that age ≥ 65 years, cardiovascular comorbidities, pre- and post-operative KPS < 80/100, post-operative neurological worsening and impaired post-operative walking ability were significantly associated with VTE. Multivariate analysis confirmed only age ≥ 65 years (p = 0.011) and post-operative KPS < 80/100 (p = 0.002) as independent risk factors for VTE. Patients operated for meningioma have a 30% risk of VTE. Age ≥ 65 years and post-operative KPS < 80 were independent risk factors for VTE.

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Authors and Affiliations

  1. Neurosurgery, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Via F. Sforza, 35, 20122, Milan, Italy

    Giorgio Carrabba, Andrea Di Cristofori, Manuela Caroli, Marco Locatelli & Paolo Rampini

  2. Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Milan, Italy

    Marco Riva

  3. Neuro Intensive Care Unit, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy

    Valeria Conte & Nino Stocchetti

  4. Nuclear Medicine, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy

    Massimo Castellani

  5. A. Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy

    Paolo Bucciarelli, Andrea Artoni & Ida Martinelli

  6. Department of Physiopathology and Transplantation, Università degli Studi di Milano, Milan, Italy

    Nino Stocchetti

Authors
  1. Giorgio Carrabba
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  2. Marco Riva
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  3. Valeria Conte
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  4. Andrea Di Cristofori
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  5. Manuela Caroli
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  6. Marco Locatelli
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  8. Paolo Bucciarelli
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  9. Andrea Artoni
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  12. Paolo Rampini
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Correspondence to Giorgio Carrabba.

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Carrabba, G., Riva, M., Conte, V. et al. Risk of post-operative venous thromboembolism in patients with meningioma. J Neurooncol 138, 401–406 (2018). https://doi.org/10.1007/s11060-018-2810-z

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  • DOI: https://doi.org/10.1007/s11060-018-2810-z

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