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Quality of life among adult patients with neurofibromatosis 1, neurofibromatosis 2 and schwannomatosis: a systematic review of the literature

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Abstract

The aim of this study was to review the literature on quality of life among adult patients with neurofibromatosis 1, neurofibromatosis 2 and schwannomatosis, and to identify the specific aspects of quality of life that were studied and reported in this population. We also set out to report predictors of quality of life. Published research reports were included if they described quality of life in this population and met methodological quality according to a list of predefined criteria. Eight studies (7 in NF1, 1 in NF2, 0 in schwannomatosis), conducted between 2001 and 2013, met inclusion criteria. The methodological quality of the eight studies was mostly high according to ratings by predefined criteria. Most studies reported that patients with NF experience decreased quality of life when compared to the general population. Visibility and disease severity were strong predictors of skin-specific quality of life in NF1 patients. However, the majority of findings regarding predictors of quality of life were weak or inconclusive. Given the decreased quality of life in NF patients, it is important to examine more comprehensively the psychosocial factors in this population, especially in patients with NF2 and schwannomatosis. Mind body interventions that address these domains may provide comprehensive and efficacious long term treatment.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Yawkey 9E, 55 Fruit Street, Boston, MA, 02114, USA

    Ana-Maria Vranceanu & Elyse Park

  2. Department of Neurology and Cancer Center, Massachusetts General Hospital, Harvard Medical School, Yawkey 9E, 55 Fruit Street, Boston, MA, 02114, USA

    Vanessa L. Merker & Scott R. Plotkin

Authors
  1. Ana-Maria Vranceanu
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  2. Vanessa L. Merker
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  3. Elyse Park
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  4. Scott R. Plotkin
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Corresponding author

Correspondence to Ana-Maria Vranceanu.

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Vranceanu, AM., Merker, V.L., Park, E. et al. Quality of life among adult patients with neurofibromatosis 1, neurofibromatosis 2 and schwannomatosis: a systematic review of the literature. J Neurooncol 114, 257–262 (2013). https://doi.org/10.1007/s11060-013-1195-2

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  • DOI: https://doi.org/10.1007/s11060-013-1195-2

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