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Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma

  • Laboratory Investigation
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Abstract

Previous studies have shown an inverse association between allergies and glioma risk; however, results for associations between single nucleotide polymorphisms (SNPs) of allergy-related genes and glioma risk have been inconsistent and restricted to a small number of SNPs. The objective of this study was to examine the association between 166 SNPs of 21 allergy-related genes and glioma risk in a nested case–control study of participants from three large US prospective cohort studies. Blood collection took place between 1982 and 1994 among the 562 included Caucasian participants (143 cases and 419 matched controls) prior to case diagnosis. Custom Illumina assay chips were used for genotyping. Logistic regression analyses, controlling for age and study cohort, were used to determine associations between each SNP and glioma risk. Statistically significant associations were found between rs2494262 and rs2427824 of the FCER1A gene, which encodes the alpha chain of the high affinity immunoglobulin E receptor, and glioma risk (nominal trend p values 0.01 and 0.03, respectively). Significant associations were also found between SNPs in IL10, ADAM33, NOS1 and IL4R and glioma risk. However, our analyses were not corrected for multiple comparisons and need to be interpreted with caution. Our findings with FCER1A SNPs provide further support for the link between allergies and risk of glioma.

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References

  1. Howlader N NA, Krapcho M, Neyman N, Aminou R, Waldron W, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA, Edwards BK (ed) (1975–2008). SEER cancer statistics review, National Cancer Institute, Bethesda

  2. Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il’yasova D, Kruchko C, McCarthy BJ, Rajaraman P, Schwartzbaum JA, Sadetzki S, Schlehofer B, Tihan T, Wiemels JL, Wrensch M, Buffler PA (2008) Brain tumor epidemiology: consensus from the brain tumor epidemiology consortium. Cancer 113(7 Suppl):1953–1968. doi:10.1002/cncr.23741

    Article  PubMed  Google Scholar 

  3. Chen C, Xu T, Chen J, Zhou J, Yan Y, Lu Y, Wu S (2011) Allergy and risk of glioma: a meta-analysis. Eur J Neurol 18(3):387–395. doi:10.1111/j.1468-1331.2010.03187.x

    Article  PubMed  CAS  Google Scholar 

  4. Linos E, Raine T, Alonso A, Michaud D (2007) Atopy and risk of brain tumors: a meta-analysis. J Natl Cancer Inst 99(20):1544–1550. doi:10.1093/jnci/djm170

    Article  PubMed  Google Scholar 

  5. Schwartzbaum J, Ding B, Johannesen TB, Osnes LT, Karavodin L, Ahlbom A, Feychting M, Grimsrud TK (2012) Association between prediagnostic IgE levels and risk of glioma. J Natl Cancer Inst 104(16):1251–1259. doi:10.1093/jnci/djs315

    Article  PubMed  CAS  Google Scholar 

  6. Calboli FC, Cox DG, Buring JE, Gaziano JM, Ma J, Stampfer M, Willett WC, Tworoger SS, Hunter DJ, Camargo CA Jr, Michaud DS (2011) Prediagnostic plasma IgE levels and risk of adult glioma in four prospective cohort studies. J Natl Cancer Inst 103(21):1588–1595. doi:10.1093/jnci/djr361

    Article  PubMed  CAS  Google Scholar 

  7. Amirian E, Liu Y, Scheurer ME, El-Zein R, Gilbert MR, Bondy ML (2010) Genetic variants in inflammation pathway genes and asthma in glioma susceptibility. Neuro Oncol 12(5):444–452. doi:10.1093/neuonc/nop057

    PubMed  CAS  Google Scholar 

  8. Brenner AV, Butler MA, Wang SS, Ruder AM, Rothman N, Schulte PA, Chanock SJ, Fine HA, Linet MS, Inskip PD (2007) Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma. Carcinogenesis 28(12):2543–2547. doi:10.1093/carcin/bgm210

    Article  PubMed  CAS  Google Scholar 

  9. Dobbins SE, Hosking FJ, Shete S, Armstrong G, Swerdlow A, Liu Y, Yu R, Lau C, Schoemaker MJ, Hepworth SJ, Muir K, Bondy M, Houlston RS (2011) Allergy and glioma risk: test of association by genotype. Int J Cancer 128(7):1736–1740. doi:10.1002/ijc.25483

    Article  PubMed  CAS  Google Scholar 

  10. Ruan Z, Zhao Y, Yan L, Chen H, Fan W, Chen J, Wu Q, Qian J, Zhang T, Zhou K, Mao Y, Zhou L, Huang Y, Lu D (2011) Single nucleotide polymorphisms in IL-4Ra, IL-13 and STAT6 genes occurs in brain glioma. Front Biosci (Elite Ed) 3:33–45

    Article  Google Scholar 

  11. Scheurer ME, Amirian E, Cao Y, Gilbert MR, Aldape KD, Kornguth DG, El-Zein R, Bondy ML (2008) Polymorphisms in the interleukin-4 receptor gene are associated with better survival in patients with glioblastoma. Clin Cancer Res 14(20):6640–6646. doi:10.1158/1078-0432.CCR-07-4681

    Article  PubMed  CAS  Google Scholar 

  12. Schoemaker MJ, Robertson L, Wigertz A, Jones ME, Hosking FJ, Feychting M, Lonn S, McKinney PA, Hepworth SJ, Muir KR, Auvinen A, Salminen T, Kiuru A, Johansen C, Houlston RS, Swerdlow AJ (2010) Interaction between 5 genetic variants and allergy in glioma risk. Am J Epidemiol 171(11):1165–1173. doi:10.1093/aje/kwq075

    Article  PubMed  Google Scholar 

  13. Schwartzbaum J, Ahlbom A, Malmer B, Lonn S, Brookes AJ, Doss H, Debinski W, Henriksson R, Feychting M (2005) Polymorphisms associated with asthma are inversely related to glioblastoma multiforme. Cancer Res 65(14):6459–6465. doi:10.1158/0008-5472.CAN-04-3728

    Article  PubMed  CAS  Google Scholar 

  14. Schwartzbaum JA, Ahlbom A, Lonn S, Malmer B, Wigertz A, Auvinen A, Brookes AJ, Collatz Christensen H, Henriksson R, Johansen C, Salminen T, Schoemaker MJ, Swerdlow AJ, Debinski W, Feychting M (2007) An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk. Cancer Epidemiol Biomarkers Prev 16(11):2448–2454. doi:10.1158/1055-9965.EPI-07-0480

    Article  PubMed  CAS  Google Scholar 

  15. Wiemels JL, Wiencke JK, Kelsey KT, Moghadassi M, Rice T, Urayama KY, Miike R, Wrensch M (2007) Allergy-related polymorphisms influence glioma status and serum IgE levels. Cancer Epidemiol Biomarkers Prev 16(6):1229–1235. doi:10.1158/1055-9965.EPI-07-0041

    Article  PubMed  CAS  Google Scholar 

  16. Belanger CF, Hennekens CH, Rosner B, Speizer FE (1978) The nurses’ health study. Am J Nurs 78(6):1039–1040

    PubMed  CAS  Google Scholar 

  17. Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A, Rosner B, Stampfer MJ (1991) Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 338(8765):464–468

    Article  PubMed  CAS  Google Scholar 

  18. Stampfer MJ, Buring JE, Willett W, Rosner B, Eberlein K, Hennekens CH (1985) The 2 × 2 factorial design: its application to a randomized trial of aspirin and carotene in U.S. physicians. Stat Med 4(2):111–116

    Article  PubMed  CAS  Google Scholar 

  19. Rich-Edwards JW, Corsano KA, Stampfer MJ (1994) Test of the National Death Index and Equifax Nationwide Death Search. Am J Epidemiol 140(11):1016–1019

    PubMed  CAS  Google Scholar 

  20. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263–265. doi:10.1093/bioinformatics/bth457

    Article  PubMed  CAS  Google Scholar 

  21. Weidinger S, Gieger C, Rodriguez E, Baurecht H, Mempel M, Klopp N, Gohlke H, Wagenpfeil S, Ollert M, Ring J, Behrendt H, Heinrich J, Novak N, Bieber T, Kramer U, Berdel D, von Berg A, Bauer CP, Herbarth O, Koletzko S, Prokisch H, Mehta D, Meitinger T, Depner M, von Mutius E, Liang L, Moffatt M, Cookson W, Kabesch M, Wichmann HE, Illig T (2008) Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet 4(8):e1000166. doi:10.1371/journal.pgen.1000166

    Article  PubMed  Google Scholar 

  22. Lee JY, Park AK, Lee KM, Park SK, Han S, Han W, Noh DY, Yoo KY, Kim H, Chanock SJ, Rothman N, Kang D (2009) Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. Carcinogenesis 30(9):1528–1531. doi:10.1093/carcin/bgp084

    Article  PubMed  CAS  Google Scholar 

  23. Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD (2010) Risk of meningioma and common variation in genes related to innate immunity. Cancer Epidemiol Biomarkers Prev 19(5):1356–1361. doi:10.1158/1055-9965.EPI-09-1151

    Article  PubMed  CAS  Google Scholar 

  24. Koppelman GH, Sayers I (2011) Evidence of a genetic contribution to lung function decline in asthma. J Allergy Clin Immunol 128(3):479–484. doi:10.1016/j.jaci.2011.05.036

    Article  PubMed  CAS  Google Scholar 

  25. Shapiro SD, Owen CA (2002) ADAM-33 surfaces as an asthma gene. New Engl J Med 347(12):936–938. doi:10.1056/NEJMcibr022144

    Article  PubMed  Google Scholar 

  26. Ibarrola-Villava M, Pena-Chilet M, Fernandez LP, Aviles JA, Mayor M, Martin-Gonzalez M, Gomez-Fernandez C, Casado B, Lazaro P, Lluch A, Benitez J, Lozoya R, Boldo E, Pizarro A, Martinez-Cadenas C, Ribas G (2011) Genetic polymorphisms in DNA repair and oxidative stress pathways associated with malignant melanoma susceptibility. Eur J Cancer 47(17):2618–2625. doi:10.1016/j.ejca.2011.05.011

    Article  PubMed  CAS  Google Scholar 

  27. Manso H, Krug T, Sobral J, Albergaria I, Gaspar G, Ferro JM, Oliveira SA, Vicente AM (2012) Variants within the nitric oxide synthase 1 gene are associated with stroke susceptibility. Atherosclerosis 220(2):443–448. doi:10.1016/j.atherosclerosis.2011.11.011

    Article  PubMed  CAS  Google Scholar 

  28. Wang TN, Tseng HI, Kao CC, Chu YT, Chen WY, Wu PF, Lee CH, Ko YC (2010) The effects of NOS1 gene on asthma and total IgE levels in Taiwanese children, and the interactions with environmental factors. Pediatr Allergy Immunol 21(7):1064–1071. doi:10.1111/j.1399-3038.2009.00981.x

    Article  PubMed  Google Scholar 

  29. Rajaraman P, Melin BS, Wang Z, McKean-Cowdin R, Michaud DS, Wang SS, Bondy M, Houlston R, Jenkins RB, Wrensch M, Yeager M, Ahlbom A, Albanes D, Andersson U, Freeman LE, Buring JE, Butler MA, Braganza M, Carreon T, Feychting M, Fleming SJ, Gapstur SM, Gaziano JM, Giles GG, Hallmans G, Henriksson R, Hoffman-Bolton J, Inskip PD, Johansen C, Kitahara CM, Lathrop M, Liu C, Le Marchand L, Linet MS, Lonn S, Peters U, Purdue MP, Rothman N, Ruder AM, Sanson M, Sesso HD, Severi G, Shu XO, Simon M, Stampfer M, Stevens VL, Visvanathan K, White E, Wolk A, Zeleniuch-Jacquotte A, Zheng W, Decker P, Enciso-Mora V, Fridley B, Gao YT, Kosel M, Lachance DH, Lau C, Rice T, Swerdlow A, Wiemels JL, Wiencke JK, Shete S, Xiang YB, Xiao Y, Hoover RN, Fraumeni JF Jr, Chatterjee N, Hartge P, Chanock SJ (2012) Genome-wide association study of glioma and meta-analysis. Hum Genet. doi:10.1007/s00439-012-1212-0

    Google Scholar 

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Acknowledgments

We thank the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA,MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. This work was supported by the National Institutes of Health [grant numbers R01 CA114205 to DSM, P01 CA097193 to JMG, P01 CA087969 to MS, P01 CA055075 to Dr. Willett]. This research complies with the current laws of the country in which it was performed.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Epidemiology, Brown Public Health, Brown University, PO Box G-S121-2, Providence, RI, 02912, USA

    Danielle M. Backes & Dominique S. Michaud

  2. School of Public Health, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK

    Afshan Siddiq, David G. Cox, Federico C. F. Calboli & Dominique S. Michaud

  3. Lyon Cancer Research Center, INSERM U1052/CNRS UMR 5286/UCBL1, Lyon, 69008, France

    David G. Cox

  4. Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, 02115, USA

    J. Michael Gaziano

  5. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USA

    Jing Ma, Meir Stampfer, David J. Hunter & Carlos A. Camargo

  6. Department of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA

    Meir Stampfer & David J. Hunter

  7. Department of Nutrition, Harvard School of Public Health, Boston, MA, 02115, USA

    Meir Stampfer & David J. Hunter

  8. Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA

    Carlos A. Camargo

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  1. Danielle M. Backes
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  2. Afshan Siddiq
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  3. David G. Cox
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  4. Federico C. F. Calboli
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  5. J. Michael Gaziano
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  6. Jing Ma
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  7. Meir Stampfer
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  8. David J. Hunter
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  9. Carlos A. Camargo
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  10. Dominique S. Michaud
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Corresponding author

Correspondence to Dominique S. Michaud.

Additional information

Danielle M. Backes and Afshan Siddiq have contributed equally to this study.

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Backes, D.M., Siddiq, A., Cox, D.G. et al. Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma. J Neurooncol 113, 229–238 (2013). https://doi.org/10.1007/s11060-013-1122-6

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  • DOI: https://doi.org/10.1007/s11060-013-1122-6

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