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Brachytherapy for brain tumors

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Abstract

Over the past several decades neurooncologists have attempted to find an adjuvant treatment that prolongs survival for patients with malignant brain tumors. Brachytherapy, radiotherapy delivered by placing radioactive sources directly into the tumor, was initially thought to be the solution to this problem. Initial single institution studies showed very promising results; however, this technique has failed to show a significant survival advantage in two randomized studies. Despite this, brachytherapy continues to be used in a number of centers throughout the world for the treatment of various types of brain tumors including low-grade gliomas, anaplastic astrocytomas, glioblastomas, meningiomas and metastases. This article reviews brachytherapy’s rationale, radiobiology, complications, indications, and results from numerous studies that have focused on its application for brain tumors with emphasis on its application for glial tumors.

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Authors and Affiliations

  1. Neurosurgical Service Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Todd W. Vitaz, Viviane Tabar & Philip H. Gutin

  2. Department of Neurological Surgery, University of Louisville School of Medicine, 210 E. Gray St., Suite 1102, Louisville, KY, 40202, USA

    Todd W. Vitaz

  3. The Department of Neurological Science, The Walton Centre for Neurology and Neurosurgery University of Liverpool, Liverpool, UK

    Peter C. Warnke

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  1. Todd W. Vitaz
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  2. Peter C. Warnke
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  3. Viviane Tabar
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  4. Philip H. Gutin
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Correspondence to Todd W. Vitaz.

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Vitaz, T.W., Warnke, P.C., Tabar, V. et al. Brachytherapy for brain tumors. J Neurooncol 73, 71–86 (2005). https://doi.org/10.1007/s11060-004-2352-4

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