Spatial memory deteriorated significantly in feeding-related operant behavior in an eight-arm radial maze in rats as a result of reactivation using a single trial without reward followed by brief reversive training (substitution of the previously reinforced arms by unreinforced). Deterioration of the initially acquired operant skill (the “old” memory) in the control reactivated group occurred for two reasons: 1) because of the use in the reactivation phase of a trial without reward, which was linked with non-receipt of food in four previously reinforced maze arms (the extinction effect) and 2) because of the formation of a “new” memory during the process of acquiring reversive learning. The result was that the conflict between the old and new memories shifted in favor of the new skill. Blockade of NMDA receptors with antagonist MK-801 partially restored the “old” memory in the reactivated group of rats due to displacement of the conflict between the old (inhibition of the extinction effect by MK-801) and new learning in favor of the old skill. Along with deterioration of the “old” memory, a “new” memory also formed during reversive training. Blockade of NMDA receptors degraded formation of the “new” memory: the rats made significantly more errors and spent more time detouring the reinforced arms than control animals. Thus, this approach identified and evaluated the manifestations of the “old” memory formed in initial learning and the appearance of the “new” memory formed by reversive learning.
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 70, No. 6, pp. 770–782, November–December, 2020.
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Zaichenko, M.I., Zakirov, P.K., Markevich, V.A. et al. MK-801 Impairs Reconsolidation of a “New” Memory and Affects the “Old” Memory in Operant Feeding-Related Behavior in an Eight-Arm Radial Maze in Rats. Neurosci Behav Physi 51, 739–747 (2021). https://doi.org/10.1007/s11055-021-01130-1
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DOI: https://doi.org/10.1007/s11055-021-01130-1