Skip to main content

Advertisement

SpringerLink
Log in

Extensive Deep Dermatophytosis Cause by Trichophyton rubrum in a Patient with Liver Cirrhosis and Chronic Renal Failure

  • Published:
Mycopathologia Aims and scope Submit manuscript

Abstract

Dermatophytes are the main pathogen of superficial skin fungal infections. On rare occasions, they can cause deep and extensive infections, especially in immunocompromised hosts. We reported a 48-year-old patient with liver cirrhosis and chronic renal failure who developed an extensive deep dermatophytosis with possible hematogenous dissemination. Skin histopathology showed extensive involvement of hair follicles and dermis by fungal elements. The pathogen was cultured from both skin biopsy specimen and central venous line. It was identified as Trichophyton rubrum by morphology and further conformed by sequencing of internal transcribed spacers of ribosomal DNA. The patient died quickly before the identification was available.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Blank F, Mann SJ. Trichophyton rubrum infections according to age, anatomical distribution and sex. Br J Dermatol. 1975;92:171–4.

    Article  PubMed  CAS  Google Scholar 

  2. Chastain MA, Reed RJ, Pankey GA. Deep dermatophytosis: report of 2 cases and review of the literature. Cutis. 2001;67:457–62.

    PubMed  CAS  Google Scholar 

  3. Voisard JJ, Weill FX, Beylot-Barry M, Vergier B, Dromer C, Beylot C. Dermatophytic granuloma caused by Microsporum canis in a heart-lung recipient. Dermatology. 1999;198:317–9.

    Article  PubMed  CAS  Google Scholar 

  4. Grossman ME, Pappert AS, Garzon MC, Silvers DN. Invasive Trichophyton rubrum infection in the immunocompromised host: report of three cases. J Am Acad Dermatol. 1995;33:315–8.

    Article  PubMed  CAS  Google Scholar 

  5. Novick NL, Tapia L, Bottone EJ. Invasive Trichophyton rubrum infection in an immunocompromised host. Case report and review of the literature. Am J Med. 1987;82:321–5.

    Article  PubMed  CAS  Google Scholar 

  6. Squeo RF, Beer R, Silvers D, Weitzman I, Grossman M. Invasive Trichophyton rubrum resembling blastomycosis infection in the immunocompromised host. J Am Acad Dermatol. 1998;39:379–80.

    Article  PubMed  CAS  Google Scholar 

  7. Wu P-Y, Cheng Y-L, Horng S-F, Shen J-L. Majocchi’s granuloma caused by Trichophyton rubrum in a renal transplant recipient. Dermatol Sinica. 2002;20:253–257.

    Google Scholar 

  8. Gong JQ, Liu XQ, Xu HB, Zeng XS, Chen W, Li XF. Deep dermatophytosis caused by Trichophyton rubrum: report of two cases. Mycoses. 2007;50:102–8.

    Article  PubMed  CAS  Google Scholar 

  9. Janniger CK. Majocchi’s granuloma. Cutis. 1992;50:267–8.

    PubMed  CAS  Google Scholar 

  10. Smith KJ, Neafie RC, Skelton HG III, Barrett TL, Graham JH, Lupton GP. Majocchi’s granuloma. J Cutan Pathol. 1991;18:28–35.

    Article  PubMed  CAS  Google Scholar 

  11. Araviysky AN, Araviysky RA, Eschkov GA. Deep generalized trichophytosis. (Endothrix in tissues of different origin). Mycopathologia. 1975;56:47–65.

    Article  PubMed  CAS  Google Scholar 

  12. Lestringant GG, Lindley SK, Hillsdon-Smith J, Bouix G. Deep dermatophytosis to Trichophyton rubrum and T. verrucosum in an immunosuppressed patient. Int J Dermatol. 1988;27:707–9.

    Article  PubMed  CAS  Google Scholar 

  13. Sentamilselvi G, Janaki C, Kamalam A, Thambiah AS. Deep dermatophytosis caused by Trichophyton rubrum–a case report. Mycopathologia. 1998;142:9–11.

    Article  PubMed  CAS  Google Scholar 

  14. Marconi VC, Kradin R, Marty FM, Hospenthal DR, Kotton CN. Disseminated dermatophytosis in a patient with hereditary hemochromatosis and hepatic cirrhosis: case report and review of the literature. Med Mycol. 2010;48:518–27.

    Article  PubMed  Google Scholar 

  15. Porubcin S, Porubcinova I, Kristian P, Virag L, Stammova E, Vyhnankova V, Paralicova Z. Invasive pulmonary aspergillosis and esophageal candidiasis in a patient with decompensated liver cirrhosis due to chronic hepatitis C and alcohol. Klin Mikrobiol Infekc Lek. 2012;18:17–21.

    PubMed  Google Scholar 

  16. Alidjinou K, Mathieu D, Colombel JF, Francois N, Poulain D, Sendid B. Triple fungal infection in a patient with liver cirrhosis. Ann Biol Clin (Paris). 2012;70:89–92.

    Google Scholar 

  17. Miranda EJ, Goncalves LG, Franca FO. Cryptococcal meningitis in HIV-negative patient with liver cirrhosis due to hepatitis C. Braz J Infect Dis. 2011;15:399–400.

    PubMed  Google Scholar 

  18. Falcone M, Massetti AP, Russo A, Vullo V, Venditti M. Invasive aspergillosis in patients with liver disease. Med Mycol. 2011;49:406–13.

    Article  PubMed  Google Scholar 

  19. Singh DK, Tyagi I, Saran RK, Gondal R. Fatal spontaneous Cryptococcal peritonitis in a woman with decompensated liver cirrhosis. Acta Cytol. 2010;54:1087–9.

    PubMed  Google Scholar 

  20. Pellicelli AM, D’Ambrosio C, Villani R, Cerasari G, Ialongo P, Cortese A, Grillo LR, Soccorsi F. Liver cirrhosis and rhino-orbital mucormycosis, a possible but rare association: description of a clinical case and literature review. Braz J Infect Dis. 2009;13:314–6.

    Article  PubMed  Google Scholar 

  21. Sikorski T, Marcinowska-Suchowierska E. Cryptococcal ascites and ascitic lymphocytosis in cirrhotic patients. Am J Med. 2007;120:e23; author reply e5.

  22. Miura T, Kawakami Y, Otsuka M, Hachiya M, Yamanoi T, Ohashi K, Suzutani T, Yamamoto T. Cutaneous cryptococcosis in a patient with cirrhosis and hepatitis C virus infection. Acta Derm Venereol. 2010;90:106–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan

    Lung-Chi Wu & Yun-Ting Chang

  2. Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan

    Lung-Chi Wu

  3. National Defense Medical Center, Taipei, Taiwan

    Lung-Chi Wu

  4. Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan

    Pei-Lun Sun

  5. Institute of Ecology and Evolutionary Biology, National Taiwan University, Taipei, Taiwan

    Pei-Lun Sun

  6. Department of Dermatology, National Yang-Ming University, No. 201, Sec. 2, Shih-Pai Rd., Taipei 112, Taiwan

    Lung-Chi Wu & Yun-Ting Chang

Authors
  1. Lung-Chi Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pei-Lun Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yun-Ting Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yun-Ting Chang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wu, LC., Sun, PL. & Chang, YT. Extensive Deep Dermatophytosis Cause by Trichophyton rubrum in a Patient with Liver Cirrhosis and Chronic Renal Failure. Mycopathologia 176, 457–462 (2013). https://doi.org/10.1007/s11046-013-9696-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11046-013-9696-2

Keywords

Search

Navigation