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Isolated Oral Histoplasmosis Presenting as Fever of Unknown Origin in a Portuguese Hemodialysis Patient

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Abstract

The authors report a clinical case of an isolated oral histoplasmosis in a hemodialysis patient that presented with fever of unknown origin and had an unremarkable physical examination. During the investigation, a Gallium scan showed uptake in the oral cavity and soon after the oral cavity examination revealed a granulomatous lesion on the tooth 26. Histopathologic findings were compatible with histoplasmosis. The treatment regimen included liposomal amphotericin B followed by itraconazole consolidation therapy, and side effects did not occur. Both clinical evolution and outcome were favorable. Oral histoplasmosis in a non-immunosuppressed patient is extremely rare.

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Authors and Affiliations

  1. Infectious Diseases Unit, University Hospitals of Coimbra, Praceta Prof. Mota Pinto, 3000-075, Coimbra, Portugal

    Nuno Marques, Ana Lebre, Lurdes Malcata, Eduardo Rabadão & José Saraiva da Cunha

  2. Stomatology Unit, University Hospitals of Coimbra, Coimbra, Portugal

    Francisco Marques

  3. Anatomo-Pathology Unit, University Hospitals of Coimbra, Coimbra, Portugal

    Maria Julião

  4. Nephrology Unit, University Hospitals of Coimbra, Coimbra, Portugal

    Luís Freitas

Authors
  1. Nuno Marques
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  2. Ana Lebre
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  3. Francisco Marques
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  4. Maria Julião
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  5. Luís Freitas
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  6. Lurdes Malcata
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  7. Eduardo Rabadão
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  8. José Saraiva da Cunha
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Correspondence to Nuno Marques.

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Marques, N., Lebre, A., Marques, F. et al. Isolated Oral Histoplasmosis Presenting as Fever of Unknown Origin in a Portuguese Hemodialysis Patient. Mycopathologia 176, 89–93 (2013). https://doi.org/10.1007/s11046-013-9641-4

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  • DOI: https://doi.org/10.1007/s11046-013-9641-4

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