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Isolated Skull Cryptococcosis in an Immunocompetent Patient

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Abstract

A 62-year-old immunocompetent rural woman who represents an isolated cryptococcal skull infection without systematic involvement is described. Diagnosis was based on positive India ink staining, positive histopathologic examination, and positive culture. Species identification was performed by growth on Sabouraud dextrose agar and CHROMagar medium and by sequencing of the intergenic and internal transcribed spacer regions of the rRNA genes. This case describes a rare presentation of Cryptococcus neoformans infection in a human immunodeficiency virus-negative patient. The lesions were significantly improved with treatment of daily oral itraconazole 400 mg. A maintenance therapy with a low-dose itraconazole was prescribed to warrant a clinical and mycological eradication. A two-year follow-up did not show any recurrence of infection.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No.81071331).

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Authors and Affiliations

  1. Department of Dermatology, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China

    Q. T. Kong, J. Feng, H. Sang, D. Q. Deng & Z. Wang

  2. Department of Urinary Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China

    W. Q. Zhou

  3. Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China

    J. Li

  4. Department of Pathology, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China

    Q. L. Shi & B. Wu

  5. Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, 210042, China

    W. D. Liu

Authors
  1. Q. T. Kong
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  2. W. Q. Zhou
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  3. J. Feng
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  4. H. Sang
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  5. D. Q. Deng
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  6. Z. Wang
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  7. J. Li
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  8. Q. L. Shi
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  9. B. Wu
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  10. W. D. Liu
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Corresponding author

Correspondence to H. Sang.

Additional information

Q. T. Kong and W. Q. Zhou are contributed equally to this work.

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Kong, Q.T., Zhou, W.Q., Feng, J. et al. Isolated Skull Cryptococcosis in an Immunocompetent Patient. Mycopathologia 175, 187–191 (2013). https://doi.org/10.1007/s11046-012-9609-9

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  • DOI: https://doi.org/10.1007/s11046-012-9609-9

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