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Virulence of Sporothrix luriei in a Murine Model of Disseminated Infection

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Abstract

Sporothrix luriei is a rare fungus causing sporotrichosis in humans. The virulence of this fungus was evaluated in a murine model of disseminated infection. Mice were challenged intravenously with two different inocula (2 × 105 and 2 × 107 CFU/animals) but only the highest one was able to kill the animals. Infected mice died between days 12 and 16, liver and spleen being the most affected organs. In the infected tissues, a massive infiltration of fungal cells and phagocytes were observed, but not the typical “eyeglass” cells described in infected human tissue.

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Authors and Affiliations

  1. Unitat d’Anatomia Patològica, Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain

    F. Fernández-Silva & E. Mayayo

  2. Unitat de Microbiologia, Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21, 43201, Reus, Tarragona, Spain

    J. Capilla & J. Guarro

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  1. F. Fernández-Silva
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  2. J. Capilla
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  3. E. Mayayo
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  4. J. Guarro
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Correspondence to J. Guarro.

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Fernández-Silva, F., Capilla, J., Mayayo, E. et al. Virulence of Sporothrix luriei in a Murine Model of Disseminated Infection. Mycopathologia 173, 245–249 (2012). https://doi.org/10.1007/s11046-011-9506-7

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  • DOI: https://doi.org/10.1007/s11046-011-9506-7

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