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Cellular retinol-binding protein 1: a therapeutic and diagnostic tumor marker

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Abstract

Cellular Retinol Binding Protein 1 (CRBP1) gene is a protein coding gene located on human chromosome 3q21, which codifies a protein named CRBP1. CRBP1 is widely expressed in many tissues as a chaperone protein to regulate the uptake, subsequent esterification and bioavailability of retinol. CRBP1 combines retinol and retinaldehyde with high affinity to protect retinoids from non-specific oxidation, and transports retinoids to specific enzymes to promote the biosynthesis of retinoic acid. The vital role of CRBP1 in retinoids metabolism has been gradually discovered, which has been implicated in tumorigenesis. However, the precise functions of CRBP1 in different diseases are still poorly understood. The purpose of this review is to provide an overview of the role of CRBP1 in various diseases, especially in both the promotion and inhibition of cancers, which may also offer a novel biomarker and potential therapeutic target for human diseases.

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Funding

This work was supported by Scientific and technological key project in Henan Province (No. 222102310244).

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Authors and Affiliations

  1. College of Life Science, Henan Normal University, Xinxiang, 453007, China

    Zhiyuan Guo, Yinshen Zhao, Yuqi Wu, Yuqi Zhang, Ruoyan Wang, Wan Liu, Chaoyang Zhang & Xianguang Yang

  2. State Key Laboratory Cultivation Base for Cell Differentiation Regulation, Henan Normal University, Xinxiang, 453007, China

    Zhiyuan Guo, Yinshen Zhao, Yuqi Wu, Yuqi Zhang, Ruoyan Wang, Wan Liu, Chaoyang Zhang & Xianguang Yang

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  1. Zhiyuan Guo
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Guo, Z., Zhao, Y., Wu, Y. et al. Cellular retinol-binding protein 1: a therapeutic and diagnostic tumor marker. Mol Biol Rep 50, 1885–1894 (2023). https://doi.org/10.1007/s11033-022-08179-2

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