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Myokine, a key cytokine for physical exercise to alleviate sarcopenic obesity

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Abstract

Skeletal muscle has a robust endocrine function as a powerful organ and can secrete and release cytokines or polypeptides known as myokines. These myokines have significant regulatory effects on signal transduction in skeletal muscle and the metabolism of peripheral tissues and organs and exert biological effects via autocrine, paracrine, or endocrine forms. Obesity and aging cause myokine secretion dysregulation, and hastening sarcopenic obesity (SO) development. Exercise is currently an excellent intervention and prevention method for SO. Meanwhile, exercise impacts many organs and tissues. These organs and tissues will produce various myokines in response to movement and metabolism throughout the body to govern muscle differentiation, growth, and remodeling. According to accumulating data, exercise can increase the release of myokines from diverse tissues into the blood and postpone the SO onset and progression by influencing protein metabolism, inflammation, mitochondrial quality control, and other mechanisms.

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Funding

This work was supported by the Graduate Research and Innovation Projects of Jiangsu Province of China (No. KYCX21_2909) and the Key Projects of Social Science Foundation of Jiangsu Province (No. 22TYA002).

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  1. Physical Education and Sport Science, Soochow University, Suzhou, Jiangsu Province, China

    Lei Zhang, Cenyi Wang, Yuanyuan Ren & Ming Yong

  2. Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, China

    Junjie Lv

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Zhang and Lv wrote and revised the paper and figure. Wang conducted the literature search. Ren and Yong guided the writing process and reviewed the manuscript. All authors critically reviewed progressive drafts of the manuscript and approved the final version.

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Correspondence to Yuanyuan Ren or Ming Yong.

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Zhang, L., Lv, J., Wang, C. et al. Myokine, a key cytokine for physical exercise to alleviate sarcopenic obesity. Mol Biol Rep 50, 2723–2734 (2023). https://doi.org/10.1007/s11033-022-07821-3

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