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Potential of stem cell therapy in intracerebral hemorrhage

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Abstract

Spontaneous intracerebral hemorrhage (ICH) is a common disease associated with high mortality and morbidity. The treatment of patients with ICH includes medical and surgical interventions. New areas of surgical intervention have been focused on the evacuation of hematoma through minimally invasive neurosurgery. In contrast, there have been no significant advances in the development of medical interventions for functional recovery after ICH. Stem cells exert multiple therapeutic functions and have emerged as a promising treatment strategy. Herein, we summarized the pathophysiology of ICH and its treatment targets, and we introduced the therapeutic mechanisms of stem cells (e.g. neutrotrophy and neuroregeneration). Moreover, we reviewed and summarized the experimental designs of the preclinical studies, including the types of cells and the timing and routes of stem cell administration. We further listed and reviewed the completed/published and ongoing clinical trials supporting the safety and efficacy of stem cell therapy in ICH. The limitations of translating preclinical studies into clinical trials and the objectives of future studies were discussed. In conclusion, current literatures showed that stem cell therapy is a promising treatment in ICH and further translation research on judiciously selected group of patients is warranted before it can be extensively applied in clinical practice.

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Acknowledgement

This work was supported by National Taiwan University Hospital (NTUH, 108C101-92). We appreciate research support from the Seventh Core Laboratory of NTUH. We also thank 7 T animal MRI Core Lab of the Neurobiology and Cognitive Science Center, NTU for technical and facility support.

Funding

This research was supported from the Seventh Core Laboratory of National Taiwan University Hospital (NTUH). This work was supported by NTUH (108C101–92).

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  1. Abel Po-Hao Huang and Yi-Hua Hsu have contributed equally to this work.

Authors and Affiliations

  1. Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan

    Abel Po-Hao Huang, Yi-Hua Hsu, Hsin-Han Tsai, Chia-Yi Su & Dar-Ming Lai

  2. Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan

    Abel Po-Hao Huang & Shan-hui Hsu

  3. Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan

    Meng-Shiue Wu & Thai-Yen Ling

  4. Department of Surgery, National Taiwan University Hospital and College of Medicine, Chung Shan S. Rd. (Zhongshan S. Rd.), Zhong-Zheng Dist, Room 815, 8th floor, research building, No.7, Taipei, 10002, Taiwan

    Dar-Ming Lai

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Huang, A.PH., Hsu, YH., Wu, MS. et al. Potential of stem cell therapy in intracerebral hemorrhage. Mol Biol Rep 47, 4671–4680 (2020). https://doi.org/10.1007/s11033-020-05457-9

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