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HLA-DRBl and susceptibility to kidney allograft rejection in Southern Iranian patients

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Abstract

Kidney transplantation is the best treatment option for the patients with end-stage renal disease. Viral infections and genetic factors such as HLA-II antigens may affect the kidney transplant outcome. The compatibility of HLA-DRB1 molecules in the survival of kidney transplant is important. Also, the correlation between these molecules and viral infections is significant. The current study investigates the allele frequency of HLA-DRB1 in 41 recipient kidney transplant and 203 normal healthy controls by polymerase chain reaction using sequence specific primers. Moreover the relation between HLA-DRB1 allelic groups and hepatitis B, hepatitis C and cytomegalovirus viral infections was also studied. However statistical analysis of the allele frequencies didn’t show any significant association between HLA-DRB1 allelic group distributions or sharing and susceptibility to acute kidney transplant rejection (P > 0.05). Comparing the allele frequencies between HLA-DRB1*14 and DRB1*04 allelic showed a significant difference in controls and patients (P = 0.03 and P = 0.05 respectively). The results of the present study also showed a significant association between possession of HLA-DRB1*07 allele in kidney transplant recipients and hepatitis C virus infection (P = 0.009). In conclusion however the results of the present study did not showed relation between HLA-DRB1 allele’s frequencies or sharing and kidney transplantation outcome, the results indicated that HLA-DRB1 alleles may susceptible individuals to renal disease or play a role in susceptibility to viral infection in kidney transplant patients.

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Acknowledgments

The authors also thanks from Transplant Research Center for financial supports.

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Authors and Affiliations

  1. Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran

    Behrouz Gharesi-Fard

  2. Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Behrouz Gharesi-Fard

  3. Islamic Azad University, Jahrom Branch, Jahrom, Iran

    Leila Rezanezhad

  4. Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Mohammad Hossein Karimi, Bita Geramizadeh, Mohammad Mehdi Salehipour, Seyed Ali Malek Hosseini & Jamshid Roozbeh

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  1. Behrouz Gharesi-Fard
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  2. Leila Rezanezhad
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  3. Mohammad Hossein Karimi
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  5. Mohammad Mehdi Salehipour
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  6. Seyed Ali Malek Hosseini
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  7. Jamshid Roozbeh
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Correspondence to Mohammad Hossein Karimi.

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Gharesi-Fard, B., Rezanezhad, L., Karimi, M.H. et al. HLA-DRBl and susceptibility to kidney allograft rejection in Southern Iranian patients. Mol Biol Rep 41, 5513–5518 (2014). https://doi.org/10.1007/s11033-014-3427-8

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  • DOI: https://doi.org/10.1007/s11033-014-3427-8

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