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Association of interleukin 23 receptor gene polymorphisms (rs10489629, rs7517847) with rheumatoid arthritis in European population: a meta-analysis

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Abstract

The interleukin 23 receptor (IL-23R) polymorphisms have been already discussed in rheumatoid arthritis (RA) repeatedly, but the results are conflict. The purpose of this meta-analysis was to assess whether IL-23R gene polymorphisms are associated with RA. We retrieved the available data from Pubmed, Medline, CNKI and CBM. Our study evaluated the effects of two polymorphisms (rs10489629, rs7517847) in European population. Pooling all the subjects, we found significant associations between the two polymorphisms and RA. For rs10489629, the pooled ORs (95 % CI) of C versus T, C/C+C/T versus T/T and C/C versus C/T+T/T were 1.092 (1.038–1.149), 1.146 (1.059–1.240) and 1.099 (1.008–1.199), respectively. For rs7517847, the combined ORs (95 % CI) of G versus T, G/G+G/T versus T/T and G/G versus G/T+T/T were 1.121 (1.063–1.183), 1.184 (1.092–1.283) and 1.133 (1.030–1.246), respectively. In conclusion, this meta-analysis demonstrates that the polymorphisms rs10489629 and rs7517847 of the IL-23R gene may be considered as risk factors for developing RA in European population.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (30830089, 81102192) and the Anhui Provincial Natural Science Foundation (11040606M183).

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The authors report no conflicts of interest.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Yu Zhai, Ke Xu, Fen Huang, Hui Peng, Chen-Chen Feng, Kao-Kao Zhu, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing Ye

  2. Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Yu Zhai, Ke Xu, Fen Huang, Hui Peng, Chen-Chen Feng, Kao-Kao Zhu, Rui-Xue Leng, Hai-Feng Pan & Dong-Qing Ye

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  1. Yu Zhai
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Correspondence to Dong-Qing Ye.

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Zhai, Y., Xu, K., Huang, F. et al. Association of interleukin 23 receptor gene polymorphisms (rs10489629, rs7517847) with rheumatoid arthritis in European population: a meta-analysis. Mol Biol Rep 39, 8987–8994 (2012). https://doi.org/10.1007/s11033-012-1768-8

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  • DOI: https://doi.org/10.1007/s11033-012-1768-8

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