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Effect of polysaccharides extract of rhizoma atractylodis macrocephalae on thymus, spleen and cardiac indexes, caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein and mRNA expression levels in aged rats

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Abstract

This study was designed to determine the possible protective effect of polysaccharides extract of rhizoma atractylodis macrocephalae on heart function in aged rats. Polysaccharides extract of rhizoma atractylodis macrocephalae was administered to aged rats. Results showed that thymus, spleen and cardiac indexs were significantly increased, whereas caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein expression, Smac/DIABLO and HtrA2/Omi mRNA expression levels were markedly reduced. It can be concluded that polysaccharides extract of rhizoma atractylodis macrocephalae may enhance immunity and improve heart function in aged rats.

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Acknowledgments

This work is supported by Shandong Provincial Natural Science Foundation (Number: Y2007C052) and the Shandong Provincial Key Technologies R & D Program of China (Project Number 2008GG30002042). Authors thank professor Mengyuan Zhang for his fund support and academic help.

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Authors and Affiliations

  1. Department of Cardiology, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, Shandong, People’s Republic of China

    Ling Guo, Yong Le Sun & Ai Hong Wang

  2. Department of Cardiac Surgery, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, Shandong, People’s Republic of China

    Chong En Xu

  3. Department of Anesthesia, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan, 250021, Shandong, People’s Republic of China

    Meng Yuan Zhang

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  1. Ling Guo
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  2. Yong Le Sun
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  3. Ai Hong Wang
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  4. Chong En Xu
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  5. Meng Yuan Zhang
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Correspondence to Chong En Xu.

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Guo, L., Sun, Y.L., Wang, A.H. et al. Effect of polysaccharides extract of rhizoma atractylodis macrocephalae on thymus, spleen and cardiac indexes, caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein and mRNA expression levels in aged rats. Mol Biol Rep 39, 9285–9290 (2012). https://doi.org/10.1007/s11033-012-1677-x

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  • DOI: https://doi.org/10.1007/s11033-012-1677-x

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