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Interleukin 1 beta −511 C/T gene polymorphism and susceptibility to febrile seizures: a meta-analysis

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Abstract

One previous meta-analysis found no evidence that interleukin 1 beta (IL-1β) −511 gene polymorphism was associated with febrile seizures (FS) by pooling a limited number of studies. However, it is necessary for the meta-analysis to reevaluate the relationship with more recent findings. Electronic databases were systematically searched for studies published before June 2011. Pooled odds ratios (OR) and 95% confidence interval (CI) were estimated by means of a genetic model free approach. Subgroup and sensitivity analyses were also performed. All statistical analyses were conducted using Stata 9.0. A total of eight studies, 728 FS cases and 1,223 controls, met the selection criteria. The results show a significant association between IL-1β −511 C/T gene polymorphism and FS (recessive genetic model TT vs. CC + CT: OR = 1.361, 95% CI: 1.065–1.738, P = 0.014). Subgroup analyses show a significant association in Asia (OR = 1.394, 95% CI: 1.005–1.935, P = 0.047), but not in Europe (OR = 1.387, 95% CI: 0.750–2.565, P = 0.298). IL-1β −511 C/T gene polymorphism may play a role in susceptibility to FS, especially in Asia. Geographic differences may be a critical factor in the risk of FS.

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Authors and Affiliations

  1. Department of Epidemiology and Statistics, School of Public Health, Anhui Medical University, Hefei, 230032, China

    Zhen-Qiang Wu, Liang Sun, Ye-Huan Sun, Yu-Hong Jiang & Xiao-Ling Lv

  2. Bureau of Epidemiology, Florida Department of Health, Tallahassee, Fl, USA

    Cizao Ren

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  1. Zhen-Qiang Wu
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  2. Liang Sun
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Correspondence to Ye-Huan Sun.

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Zhen-Qiang Wu and Liang Sun contributed equally to this work.

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Wu, ZQ., Sun, L., Sun, YH. et al. Interleukin 1 beta −511 C/T gene polymorphism and susceptibility to febrile seizures: a meta-analysis. Mol Biol Rep 39, 5401–5407 (2012). https://doi.org/10.1007/s11033-011-1340-y

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  • DOI: https://doi.org/10.1007/s11033-011-1340-y

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