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Class 1 integron in staphylococci

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Abstract

As a major concern in public health, methicillin-resistant staphylococci (MRS) still remains one of the most prevalent pathogens that cause nosocomial infections throughout the world and has been recently labeled as a “super bug” in antibiotic resistance. Thus, surveillance and investigation on antibiotic resistance mechanisms involved in clinical MRS strains may raise urgent necessity and utmost significance. As a novel antibiotic resistance mechanism, class 1 integron has been identified as a primary source of antimicrobial resistance genes in Gram-negative organisms. However, most available studies on integrons had been limited within Gram-negative microbes, little is known for clinical Gram-positive bacteria. Based on series studies of systematic integrons investigation in hundreds of staphylococci strains during 2001–2006, this review concentrated on the latest development of class 1 integron in MRS isolates, including summary of prevalence and occurrence of class 1 integron, analysis of correlation between integron and antibiotic resistance, further demonstration of the role integrons play as antibiotic determinants, as well as origin and evolution of integron-associated gene cassettes during this study period.

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Acknowledgments

We sincerely thank Dr. Jin Chu from University of Leeds for her excellent work in technical support and data analysis. We are also highly appreciated for the SCCmec type strains of MRSA provided by Dr. Teruyo Ito and Dr. Keiichi Hiramatsu from Juntendo University. This work was supported by National Institute of Allergy and Infectious Diseases, National Institutes of Health grant R01 AI69568-01A2 and State Scholarship Fund of China Scholarship Council (2008615044).

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  1. College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China

    Zhenbo Xu, Lin Li & Lei Shi

  2. Department of Microbial Pathogenesis, Dental School, University of Maryland, Baltimore, MD, 21201, USA

    Zhenbo Xu & Mark E. Shirtliff

  3. Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan

    Lei Shi

  4. Department of Microbiology and Immunology, School of Medicine, University of Maryland, Room #9209, 650W. Baltimore Street, Baltimore, MD, 21201, USA

    Mark E. Shirtliff

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Xu, Z., Li, L., Shi, L. et al. Class 1 integron in staphylococci. Mol Biol Rep 38, 5261–5279 (2011). https://doi.org/10.1007/s11033-011-0676-7

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