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Employing of Fe3O4/CuO/ZnO@MWCNT MNCs in the solvent-free synthesis of new cyanopyrroloazepine derivatives and investigation of biological activity

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Abstract

In this research, we synthesized the Fe3O4/CuO/ZnO@MWCNT magnetic nanocomposites using water extract of Petasites hybridus rhizome, and the high performance of synthesized catalyst was confirmed by using in the solvent-free multicomponent reactions of isatoic anhydride, N-methylimidazole, alkyl bromides, activated acetylenic compounds and 2-aminoacetonitrile at ambient temperature for the production of new cyanopyrroloazepine derivatives in high yields. This catalyst could be used several times in these reactions and have main role in the yield of product. The synthesized cyanopyrroloazepines have NH groups in their structure and for this reason have good antioxidant activity. Also, employing Gram-positive and Gram-negative bacteria in the disk diffusion procedure confirmed some cyanopyrroloazepines antimicrobial effect. The results showed that synthesized cyanopyrroloazepine prevented the bacterial growth. This used process for preparation of new cyanopyrroloazepine has some improvements such as low reaction time, product with high yields, simple separation of catalyst and products.

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Acknowledgements

The authors gratefully acknowledge the support of the Research Council of Islamic Azad University of East Tehran Branch

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  1. Department of Chemistry, East Tehran Branch, Islamic Azad University, P.O. Box 18735-138, Tehran, Iran

    Neda Zare Davijani, Reza Kia-Kojoori, Shahrzad Abdolmohammadi & Sepehr Sadegh-Samiei

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  1. Neda Zare Davijani
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  2. Reza Kia-Kojoori
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  3. Shahrzad Abdolmohammadi
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  4. Sepehr Sadegh-Samiei
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Correspondence to Reza Kia-Kojoori.

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Zare Davijani, N., Kia-Kojoori, R., Abdolmohammadi, S. et al. Employing of Fe3O4/CuO/ZnO@MWCNT MNCs in the solvent-free synthesis of new cyanopyrroloazepine derivatives and investigation of biological activity. Mol Divers 26, 2121–2134 (2022). https://doi.org/10.1007/s11030-021-10319-y

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  • DOI: https://doi.org/10.1007/s11030-021-10319-y

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