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Evaluation of the target-specific therapeutic potential of herbal compounds for the treatment of cancer

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Abstract

Cancer is among one of the most fatal diseases leading to millions of death around the globe. Chemotherapy is the most popular conventional approach for the treatment of cancer. However, this is usually associated with various side effects and puts the patients under extreme physical and mental stress. Besides, there are increasing concerns about drug resistance. Thus, to surmount these limitations, there is a need to explore some alternative treatments. Studies related to plant-derived compounds are crucial in the search for safer and more efficient treatments. Plants and their associated secondary metabolites have been a revolutionary approach in the field of cancer treatment, as they give answers to almost all the constraints faced by synthetic drugs. Various plants and associated secondary metabolites display a great prospective as cytotoxic anticancer agents due to their specific interference with validated drug targets, such as inhibitors of mitosis, topoisomerase I and II inhibitor, DNA interactive agent, protein kinase inhibitors, inhibitors of DNA synthesis. In this review, the therapeutic potential of various natural compounds and their derivatives are presented based on their molecular targets. These herbal compounds and their derivatives could provide a rich resource for novel anticancer drug development.

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Acknowledgements

Authors are thankful to the Department of Zoology, Kumaun University SSJ Campus, Almora (Uttarakhand), India, for providing the facility for this work. This work is supported by DSTFIST Grant SR/FST/LS- I/2018/131 to Department of Zoology.

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  1. Cell and Molecular Biology Laboratory, Department Of Zoology, Kumaun University, SSJ Campus, Almora, Uttarakhand, India

    Shobha Upreti, Satish Chandra Pandey, Ila Bisht & Mukesh Samant

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Upreti, S., Pandey, S.C., Bisht, I. et al. Evaluation of the target-specific therapeutic potential of herbal compounds for the treatment of cancer. Mol Divers 26, 1823–1835 (2022). https://doi.org/10.1007/s11030-021-10271-x

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  • DOI: https://doi.org/10.1007/s11030-021-10271-x

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