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Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives

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Abstract

We synthesized a series of novel pyrrole- and pyrazole-substituted coumarin derivatives and evaluated their antifungal activity against six phytopathogenic fungi in vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds 5g, 6a, 6b, 6c, 6d and 6h exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Furthermore, compound 5g displayed stronger antifungal activity against Rhizoctorzia solani (EC50 = 15.4 µg/mL) than positive control Osthole (EC50 = 67.2 µg/mL).

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Acknowledgements

The authors are grateful to the Program of National Key R&D Program of China (2018YFD0200103) and the Fundamental Research Funds for the Central Universities (KYTZ 201604) for partially funding this work.

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Authors and Affiliations

  1. Jiangsu Key Laboratory of Pesticide, College of Sciences, Nanjing Agricultural University, Nanjing, 210095, People’s Republic of China

    Shu-Guang Zhang, Chao-Gen Liang, Yue-Qing Sun, Peng Teng, Jia-Qun Wang & Wei-Hua Zhang

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  2. Chao-Gen Liang
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Zhang, SG., Liang, CG., Sun, YQ. et al. Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives. Mol Divers 23, 915–925 (2019). https://doi.org/10.1007/s11030-019-09920-z

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