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Indium triflate promoted one-pot multicomponent synthesis of structurally diverse 3-amino-imidazo[1,2-a]pyridines

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Abstract

An efficient, mild, and expeditious synthetic protocol has been developed for the synthesis of structurally diverse 3-amino-imidazo[1,2-a]pyridines, involving a three-component, one-pot cyclocondensation reaction of 2-aminobenzothiazole/2-aminoazines, ethyl isocyanoacetate/tert-butyl isocyanides, and pyrazole-3(4)-carbaldehyde/substituted aromatic carbonyl compounds in 45 min. using In(OTf)\(_{3}\) as a catalyst in toluene. Mild reaction conditions, high atom economy, operational simplicity, short reaction time, and structural diversity with high product conversion are among the advantages of the present synthetic protocol.

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Acknowledgments

R. S. and A. A. thank Manipal University Jaipur for seed money grant. S. S. thanks MUJ for teaching assistantship. Material Research Center, MNIT, Jaipur is also thanked for spectral analysis of synthesized compounds.

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  1. Department of Chemistry, Manipal University Jaipur, VPO-Dehmi Kalan, Teshil-Sanganer, Off Jaipur Ajmer Expressway, Jaipur, Rajasthan, 303007, India

    Suman Swami, Arunava Agarwala & Rahul Shrivastava

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  1. Suman Swami
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  2. Arunava Agarwala
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Correspondence to Rahul Shrivastava.

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Swami, S., Agarwala, A. & Shrivastava, R. Indium triflate promoted one-pot multicomponent synthesis of structurally diverse 3-amino-imidazo[1,2-a]pyridines. Mol Divers 21, 81–88 (2017). https://doi.org/10.1007/s11030-016-9699-2

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