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Unravelling the potential neuroprotective facets of erythropoietin for the treatment of Alzheimer’s disease

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Abstract

During the last three decades, recombinant DNA technology has produced a wide range of hematopoietic and neurotrophic growth factors, including erythropoietin (EPO), which has emerged as a promising protein drug in the treatment of several diseases. Cumulative studies have recently indicated the neuroprotective role of EPO in preclinical models of acute and chronic neurodegenerative disorders, including Alzheimer’s disease (AD). AD is one of the most prevalent neurodegenerative illnesses in the elderly, characterized by the accumulation of extracellular amyloid-ß (Aß) plaques and intracellular neurofibrillary tangles (NFTs), which serve as the disease’s two hallmarks. Unfortunately, AD lacks a successful treatment strategy due to its multifaceted and complex pathology. Various clinical studies, both in vitro and in vivo, have been conducted to identify the various mechanisms by which erythropoietin exerts its neuroprotective effects. The results of clinical trials in patients with AD are also promising. Herein, it is summarized and reviews all such studies demonstrating erythropoietin’s potential therapeutic benefits as a pleiotropic neuroprotective agent in the treatment of Alzheimer’s disease.

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  1. Dapinder Kaur and Tapan Behl contributed equally to this work.

Authors and Affiliations

  1. Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India

    Dapinder Kaur, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma & Vishnu Nayak Badavath

  2. School of Medicine and Pharmaceutical Sciences, Zhejiang University, Hangzhou, China

    Syed Shams ul Hassan

  3. Department of Biochemistry and Molecular Biology, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh

    Mohammad Mehedi Hasan

  4. Natural & Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman

    Saurabh Bhatia & Ahmed Al-Harassi

  5. Amity Institute of Pharmacy, Amity University, Noida, Haryana, India

    Saurabh Bhatia

  6. Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, Pakistan

    Haroon Khan

  7. Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania

    Simona Bungau

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DK, TB: Conceived the idea and wrote the article; AS, MMH and SB: Figure Work; SS, NS, and AAH: Literature Search; VNB and SSH: Language Revision HK and SBU: Proof Read.

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Kaur, D., Behl, T., Sehgal, A. et al. Unravelling the potential neuroprotective facets of erythropoietin for the treatment of Alzheimer’s disease. Metab Brain Dis 37, 1–16 (2022). https://doi.org/10.1007/s11011-021-00820-6

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