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Crosstalk between ferroptosis and macrophages: potential value for targeted treatment in diseases

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Abstract

Ferroptosis is a newly identified form of programmed cell death that is connected to iron-dependent lipid peroxidization. It involves a variety of physiological processes involving iron metabolism, lipid metabolism, oxidative stress, and biosynthesis of nicotinamide adenine dinucleotide phosphate, glutathione, and coenzyme Q10. So far, it has been discovered to contribute to the pathological process of many diseases, such as myocardial infarction, acute kidney injury, atherosclerosis, and so on. Macrophages are innate immune system cells that regulate metabolism, phagocytize pathogens and dead cells, mediate inflammatory reactions, promote tissue repair, etc. Emerging evidence shows strong associations between macrophages and ferroptosis, which can provide us with a deeper comprehension of the pathological process of diseases and new targets for the treatments. In this review, we summarized the crosstalk between macrophages and ferroptosis and anatomized the application of this association in disease treatments, both non-neoplastic and neoplastic diseases. In addition, we have also addressed problems that remain to be investigated, in the hope of inspiring novel therapeutic strategies for diseases.

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Acknowledgements

There is no financial conflict of interest between the authors. The authors would like to acknowledge the support of fundings. The authors would like to thank graphics program Adobe Illustrator and smart.servier.com for supporting.

Funding

This work was supported by grants from the National Natural Science Foundation of China (Grant No. 82001037), the Natural Science Foundation of Sichuan Province (Grant No. 2022NSFSC0751) and the Research and Develop Program, West China Hospital of Stomatology, Sichuan University (Grant No. RD-02-202007) for Xuelian Tan.

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Authors and Affiliations

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics West China Hospital of Stomatology, Sichuan University, 14# 3rd Section, Renmin South Road, Chengdu, 610041, Sichuan, China

    Wanxin Lan, Lei Yang & Xuelian Tan

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  1. Wanxin Lan
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  2. Lei Yang
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  3. Xuelian Tan
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XT conceived and designed the study. WL drafted the manuscript. LY polished the language. WL, LY and XT searched and reviewed the literature, and created the figures and tables. All of the authors critically reviewed and revised the manuscript. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Xuelian Tan.

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Lan, W., Yang, L. & Tan, X. Crosstalk between ferroptosis and macrophages: potential value for targeted treatment in diseases. Mol Cell Biochem (2023). https://doi.org/10.1007/s11010-023-04871-4

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