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RNA m6A methylation regulators in sepsis

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Abstract

N6-methyladenosine (m6A) modification is a class of epitope modifications that has received significant attention in recent years, particularly in relation to its role in various diseases, including sepsis. Epigenetic research has increasingly focused on m6A modifications, which is influenced by the dynamic regulation of three protein types: ‟Writers” (such as METTL3/METTL14/WTAP)—responsible for m6A modification; ‟Erasers” (FTO and ALKBH5)—involved in m6A de-modification; and ‟Readers” (YTHDC1/2, YTHDF1/2/3)—responsible for m6A recognition. Sepsis, a severe and fatal infectious disease, has garnered attention regarding the crucial effect of m6A modifications on its development. In this review, we attempted to summarize the recent studies on the involvement of m6A and its regulators in sepsis, as well as the significance of m6A modifications and their regulators in the development of novel drugs and clinical treatment. The potential value of m6A modifications and modulators in the diagnosis, treatment, and prognosis of sepsis has also been discussed.

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Abbreviations

AKI:

Acute kidney injury

ALI:

Acute lung injury

ARDS:

Acute respiratory distress syndrome

ALKBH5:

Alkylation repair homolog 5

CXCR2:

CXC chemokine receptor 2

eIF3:

Eukaryotic initiation factor 3

FTO:

Fat mass and obesity-associated protein

I/R:

Ischemia/reperfusion

LDH:

Lactate dehydrogenase

LPS:

Lipopolysaccharide

HNRNP:

Nuclear inhomogeneous nuclear ribonucleoprotein

IGF2BP:

Insulin-like growth factor 2 mRNA-binding protein

MALAT1:

Metastasis-associated lung adenocarcinoma tran 1

METTL3:

Methyltransferase-like 3

NETs:

Neutrophil extracellular traps

PH:

Pulmonary hypertension

PMVECs:

Pulmonary microvascular endothelial cells

SAE:

Sepsis-associated encephalopathy

SOCS:

Suppressor of cytokine signaling

SH2:

Src-homology 2

SIRS:

Systemic inflammatory response syndrome

YTH:

YT521-B homolog

YTHDF2:

YTH structural domain family 2

WTAP:

Wilms tumor 1-associated protein

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Acknowledgements

The authors would like to thank all of the reviewers who participated in the review and MJEditor (www.mjeditor.com) for their linguistic assistance during the preparation of the manuscript.

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  1. Lin Zhu and Hairong Zhang have contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China

    Lin Zhu & Xiaoyu Zhang

  2. Department of Obstetrics and Gynecology, Shandong Provincial Third Hospital, Jinan, 250031, People’s Republic of China

    Hairong Zhang

  3. Department of Pathology, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of China

    Lei Xia

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  1. Lin Zhu
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  2. Hairong Zhang
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LZ and HRZ designed the study and wrote the manuscript; LZ and XYZ researched the literature and drafted the manuscript; HRZ and LX reviewed the manuscript.

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Correspondence to Hairong Zhang or Lei Xia.

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Zhu, L., Zhang, H., Zhang, X. et al. RNA m6A methylation regulators in sepsis. Mol Cell Biochem (2023). https://doi.org/10.1007/s11010-023-04841-w

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