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Association Between Maternal Multivitamin Use and Preterm Birth in 24 States, Pregnancy Risk Assessment Monitoring System, 2009–2010

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Abstract

Objectives The study objective was to examine the prevalence of maternal multivitamin use and associations with preterm birth (<37 weeks gestation) in the United States. We additionally examined whether associations differed by race/ethnicity. Methods Using the Pregnancy Risk Assessment Monitoring System, we analyzed 2009–2010 data among women aged ≥18 years with a singleton live birth who completed questions on multivitamin use 1 month prior to pregnancy (24 states; n = 57,348) or in the last 3 months of pregnancy (3 states, n = 5095). Results In the month prior to pregnancy, multivitamin use ≥4 times/week continued to remain low (36.8 %). In the last 3 months of pregnancy, 79.6 % of women reported using multivitamins ≥4 times/week. Adjusting for confounders, multivitamin use 1–3 times/week or ≥4 times/week prior to pregnancy was not associated with preterm birth overall. Though there was no evidence of dose response, any multivitamin use in the last 3 months of pregnancy was associated with a significant reduction in preterm birth among non-Hispanic black women. Conclusions for Practice Multivitamin use during pregnancy may help reduce preterm birth, particularly among populations with the highest burden, though further investigations are warranted.

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Abbreviations

CDC:

Centers for Disease Control and Prevention

CI:

Confidence interval

NHB:

Non-Hispanic black

NHW:

Non-Hispanic white

OR:

Odds ratio

PRAMS:

Pregnancy Risk Assessment Monitoring System

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Acknowledgments

The authors would like to acknowledge CDC and the Pregnancy Risk Assessment Monitoring System working group: Alabama—Qun Zheng, MS; Alaska—Kathy Perham-Hester, MS, MPH; Arkansas—Mary McGehee, PhD; Colorado—Alyson Shupe, PhD; Connecticut—Jennifer Morin, MPH; Delaware—George Yocher, MS; Florida— Kelsi E.l Williams; Georgia—Chinelo Ogbuanu, MD, MPH, PhD; Hawaii—Jane Awakuni; Illinois—Theresa Sandidge, MA; Iowa—Sarah Mauch, MPH; Louisiana—Amy Zapata, MPH; Maine—Tom Patenaude, MPH; Maryland—Diana Cheng, MD; Massachusetts—Emily Lu, MPH; Michigan—Patricia McKane; Minnesota—Judy Punyko, PhD, MPH; Mississippi—Brenda Hughes, MPPA; Missouri—Venkata Garikapaty, MSc, MS, PhD, MPH; Montana—JoAnn Dotson; Nebraska—Brenda Coufal; New Hampshire—David J. Laflamme, PhD, MPH; New Jersey—Ingrid M. Morton, MS; New Mexico—Eirian Coronado, MPH; New York State—Anne Radigan-Garcia; New York City—Candace Mulready-Ward, MPH; North Carolina—Kathleen Jones-Vessey, MS; North Dakota—Sandra Anseth; Ohio—Connie Geidenberger PhD; Oklahoma—Alicia Lincoln, MSW, MSPH; Oregon—Kenneth Rosenberg, MD, MPH; Pennsylvania—Tony Norwood; Rhode Island—Sam Viner-Brown, PhD; South Carolina—Mike Smith, MSPH; Texas—Rochelle Kingsley, MPH; Tennessee—Ramona Lainhart, PhD; Utah—Laurie Baksh, MPH; Vermont—Peggy Brozicevic; Virginia—Christopher Hill, MPH, CPH; Washington—Linda Lohdefinck; West Virginia—Melissa Baker, MA; Wisconsin—Katherine Kvale, PhD; Wyoming—Amy Spieker, MPH; CDC PRAMS Team, Applied Sciences Branch, Division of Reproductive Health.

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Authors and Affiliations

  1. Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, MS F-74, Atlanta, GA, 30341, USA

    Emily O. Johnston & Andrea J. Sharma

  2. U.S. Public Health Service Commissioned Corps, Atlanta, GA, USA

    Andrea J. Sharma & Karon Abe

  3. Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Road, MS E-64, Atlanta, GA, 30333, USA

    Karon Abe

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  1. Emily O. Johnston
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Correspondence to Emily O. Johnston.

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The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

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Johnston, E.O., Sharma, A.J. & Abe, K. Association Between Maternal Multivitamin Use and Preterm Birth in 24 States, Pregnancy Risk Assessment Monitoring System, 2009–2010. Matern Child Health J 20, 1825–1834 (2016). https://doi.org/10.1007/s10995-016-1985-1

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