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Role of Lateral Hypothalamus Area in the Central Regulation of Feeding

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International Journal of Peptide Research and Therapeutics Aims and scope Submit manuscript

Abstract

Several mechanisms both inside and outside the central nervous system (CNS) collaborate to control feeding. The hypothalamus received food-related messages from different regions of the brain, and exports appropriate output through specific hypothalamic nuclei. One of the most important of these hypothalamic nuclei is the lateral hypothalamus area (LHA). In this review, multiple valid papers from electronic sources (including Web of Science, Scopus, PubMed, SID, Google Scholar, and ISI databases) were used; which in them the role of LHA in the central regulation of feeding investigated. The hypothalamus is responsible for the central control of food intake in the CNS. The arcuate nucleus, paraventricular nucleus, and LHA are specific regions in the hypothalamus that regulate food intake. The LHA is considered to be the center of hunger or feeding among these nuclei. With the interaction of orexigenic and anorexigenic neurons, as well as various neurotransmitters in several neuronal pathways, this nucleus produces increased food intake. The LHA eventually improved food intake via extensive brain connections. The LHA via various neurons and synaptic connections with other special hypothalamic nuclei involved in the control of nutritional behavior (graphical abstract) stimulated food intake.

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Abbreviations

LHA:

Lateral hypothalamus area

PNS:

Peripheral nervous system

ARC:

Arcuate nucleus

PVN:

Paraventricular nucleus

AgRP:

Agouti-related protein

POMC:

Pro-opiomelanocortin

BNTS:

Bed nucleus of the stria terminalis

GABA:

Gamma-aminobutyric acid

GI:

Glucose-inhibition

GE:

Glucose-excited

CART:

Cocaine-amphetamine regulated transcript

BBB:

Blood–brain barrier

GLUTs:

Glucose transporters

SGLTs:

Sodium–glucose co-transporters

NPYR:

Neuropeptide Y receptor

α-MSH:

α-Melanocortin stimulating hormone

MC4R:

Melanocortin stimulating 4 receptor

ICV:

Intracerebroventricular injection

CRH:

Corticotropin-releasing hormone

Lp-R:

Leptin receptor

CNS:

Central nervous system

GPCR:

G protein-coupled receptor

OXR:

Orexin receptors

IR:

Insulin receptors

CAMP:

Cyclic adenosine monophosphate

GHSR1a:

Growth hormone secretagogue receptor 1a

NTs-R:

Neurotensin receptor

GalR1:

Galanin-receptor1

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Acknowledgements

The authors thank the Ferdowsi University of Mashhad for their cooperation and support of this article.

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  1. Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

    Shiba Yousefvand & Farshid Hamidi

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  1. Shiba Yousefvand
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Correspondence to Farshid Hamidi.

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Yousefvand, S., Hamidi, F. Role of Lateral Hypothalamus Area in the Central Regulation of Feeding. Int J Pept Res Ther 28, 83 (2022). https://doi.org/10.1007/s10989-022-10391-4

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