Skip to main content

Advertisement

SpringerLink
Log in

Interaction Between Nociceptin/Orphanin FQ and Adrenergic System on Food Intake in Neonatal Chicken

  • Published:
International Journal of Peptide Research and Therapeutics Aims and scope Submit manuscript

Abstract

The information emerging from the studies demonstrates adrenergic system and nociceptin/orphanin FQ (N/OFQ) play a crucial role on appetite regulation but there is no information for their interaction. The purpose of this study was to examine the effects of intracerebroventricular (ICV) injection of prazosin (α1 receptor antagonist), yohimbine (α2 receptor antagonist), metoprolol (β1 adrenergic receptor antagonist), ICI 118,551 (β2 adrenergic receptor antagonist) and SR59230R (β3 adrenergic receptor antagonist) on N/OFQ-induced hyperphagia by 3-h food-deprived neonatal broiler chicken. In experiment 1, chicken injected with saline, prazosin (10 nmol), N/OFQ (16 nmol) and co-injection of prazosin + N/OFQ. In experiment 2, ICV injection of saline, yohimbine (13 nmol), N/OFQ (16 nmol) and yohimbine + N/OFQ applied to the birds. In experiment 3, injections were saline, metoprolol (24 nmol), N/OFQ (16 nmol) and metoprolol + N/OFQ. In experiment 4, the birds received ICV injection of saline, ICI 118,551 (5 nmol), (C) N/OFQ (16 nmol) and co-administration of ICI 118,551 + N/OFQ. In experiment 5, chicken injected with saline, SR59230R (20 nmol), N/OFQ (16 nmol) and SR59230R + N/OFQ. Then, cumulative food intake was recorded until 120 min after injection. According to the results, ICV injection of N/OFQ significantly increased food intake (P < 0.001). The effect of N/OFQ significantly amplified by co-injection of N/OFQ + β2 adrenergic receptor antagonist (P < 0.001). Also, administration of β1 or β3 adrenergic receptor antagonist had no effect on N/OFQ-induced hyperphagia (P > 0.05). These results suggest that the effect of N/OFQ on cumulative food intake is mediated via β2 adrenergic receptors in neonatal chicken.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  • Abbasnejad M, Jonaidi H, Denbow DM, Pour Rahimi AM (2005) Feeding and locomotion responses to centrally injected nociceptin/orphanin FQ in chicks. Physiol Behav 85:383–386

    Article  CAS  PubMed  Google Scholar 

  • Alizadeh A, Zendehdel M, Babapour V, Charkhkar S, Hassanpour S (2015) Role of cannabinoidergic system on food intake in neonatal layer-type chicken. Vet Res Commun 39:151–157

    Article  PubMed  Google Scholar 

  • Alt C, Lam JS, Harrison MT, Kershaw KM, Samuelsson S, Toll L, D’Andrea A (2012) Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis. Eur J Pharmacol 683:285–293

    Article  CAS  PubMed  Google Scholar 

  • Baghbanzadeh A, Hajinezhad MR, Shohreh B, Maleklou R (2010) Intralateral hypothalamic area injection of isoproterenol and propranolol affects food and water intake in broilers. J Comp Physiol A 196:221–226

    Article  CAS  Google Scholar 

  • Barnes MJ, Holmes G, Primeaux SD, York DA, Bray GA (2006) Increased expression of mu opioid receptors in animals susceptible to dietinduced obesity. Peptides 27:3292–3298

    Article  CAS  PubMed  Google Scholar 

  • Bewick GA, Dhillo WS, Darch SJ, Murphy KG, Gardiner JV, Jethwa PH et al (2005) Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release. Endocrinology 146(8):3526–3534

    Article  CAS  PubMed  Google Scholar 

  • Blevins JE, Stanley BG, Reidelberger RD (2002) DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. Pharmacol Biochem Behav 71:277–282

    Article  CAS  PubMed  Google Scholar 

  • Bungo T, Dodo K, Kawamura K, Izumi T, Ueda H (2005) Effects of various µ- and δ-opioid ligands on food intake in the meat-type chick. Physiol Behav 85:519–523

    Article  CAS  PubMed  Google Scholar 

  • Bungo T, Shimojo M, Masuda Y, Choi YH, Denbow DM, Furuse M (1999) Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick. Brain Res 826:313–316

    Article  CAS  PubMed  Google Scholar 

  • Bungo T, Shiraishi J, Yanagita K, Ohta Y, Fujita M (2009) Effect of nociceptin/orphanin FQ on feeding behavior and hypothalamic neuropeptide expression in layer-type chicks. Gen Comp Endocrinol 163:47–51

    Article  CAS  PubMed  Google Scholar 

  • Chen RZ, Frassetto A, Fong TM (2006) Effects of the CB1 cannabinoid receptor inverse agonist AM251 on food intake and body weight in mice lacking l-opioid receptors. Brain Res 1108:176–178

    Article  CAS  PubMed  Google Scholar 

  • Ciccocioppo R, Cippitelli A, Economidou D, Fedeli A, Massi M (2004) Nociceptin/orphanin FQ acts as a functional antagonist of corticotropin-releasing factor to inhibit its anorectic effect. Physiol Behav 82:63–68

    Article  CAS  PubMed  Google Scholar 

  • D’Addario C, Micioni Di Bonaventura MV, Puccia M, Romano A, Gaetani S, Ciccocioppo R, Cifani C, Maccarrone M (2014) Endocannabinoid signaling and food addiction. Neurosci Biobehav Rev 47:203–224

    Article  PubMed  Google Scholar 

  • Date Y, Shimbara T, Koda S, Toshinai K, Ida T, Murakami N, Miyazato M, Kokame K, Ishizuka Y, Ishida Y, Kageyama H, Shioda S, Kangawa K, Nakazato M (2006) Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus. Cell Metab 4:323–331

    Article  CAS  PubMed  Google Scholar 

  • Davis JL, Masuoka DT, Gerbrandt LK, Cherkin A (1979) Autoradiographic distribution of l-proline in chicks after intracerebral injection. Physiol Behav 22:693–695

    Article  CAS  PubMed  Google Scholar 

  • Denbow DM (1994) Peripheral regulation of food intake in poultry. J Nutr 124:1349S–1354S

    CAS  PubMed  Google Scholar 

  • Denbow DM (1999) Food intake regulation in birds. J Exp Zool 283:333–338

    Article  Google Scholar 

  • Denbow DM, Cherry JA, Siegel PB, Van Kery HP (1981) Eating, drinking and temperature response of chicks to brain catecholamine injections. Physiol Behav 27:265–269

    Article  CAS  PubMed  Google Scholar 

  • Denbow DM, Sheppard BJ (1993) Food and water intake responses of the domestic fowl to norepinephrine infusion at circumscribed neural sites. Brain Res Bull 31:121–128

    Article  CAS  PubMed  Google Scholar 

  • Economidou D, Policani F, Angellotti T, Massi M, Terada T, Ciccocioppo R (2006) Effect of novel NOP receptor ligands on food intake in rats. Peptides 27:775–783

    Article  CAS  PubMed  Google Scholar 

  • Furuse M, Ando R, Bungo T, Ao R, ShimoJO M, Masuda Y (1999) Intracerebroventricular injection of orexins does not stimulate food intake in neonatal chicks. Br Poult Sci 40:698–700

    Article  CAS  PubMed  Google Scholar 

  • Furuse M, Matsumoto M, Saito N, Sugahara K, Hasegawa S (1997) The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick. Eur J Pharmacol 339:211–214

    Article  CAS  PubMed  Google Scholar 

  • Gavioli EC, Calo G (2013) Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs. Pharmacol Ther 140(1):10–25

    Article  CAS  PubMed  Google Scholar 

  • Hassanpour S, Zendehdel M, Babapour V, Charkhkar S (2015) Endocannabinoid and nitric oxide interaction mediates food intake in neonatal chicken. Br Poult Sci 56(4):443–451

    Article  CAS  PubMed  Google Scholar 

  • Jonaidi H, Noori Z (2012) Neuropeptide Y-induced feeding is dependent on GABAA receptors in neonatal chicks. J Comp Physiol A 198:827–832

    Article  CAS  Google Scholar 

  • Kanzler SA, Januario AC, Paschoalini MA (2011) Involvement of β3 -adrenergic receptors in the control of food intake in rats. Braz J Med Biol Res 44(11):1141–1147

    Article  CAS  PubMed  Google Scholar 

  • Lei S (2014) Cross interaction of dopaminergic and adrenergicsystems in neural modulation. Int J Physiol Pathophysiol Pharmacol 6(3):137–142

    CAS  PubMed  PubMed Central  Google Scholar 

  • Marti M, Stocchi S, Paganini F, Mela F, Risi CD, Calo G, Guerrini R, BArnes TA, LAmbert DG, Beani L, Bianchi C, Morari M (2003) Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex. Br J Pharmacol 138:91–98

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Olanrewaju HA, Thaxton JP, Dozier WA, Purswell J, Roush WB, Branton SL (2006) A review of lighting programs for broiler production. Int J Poult Sci 5(4):301–308

    Article  Google Scholar 

  • Olszewski PK, Grace MK, Fard SS, Grevès ML, Klockars A, Massi M, Schiöth HB, Levine AS (2010) Central nociceptin/orphanin FQ system elevates food consumption by both increasing energy intake and reducing aversive responsiveness. Am J Physiol Regul Integr Comp Physiol 299:R655–R663

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Polidori C, de Caro G, Massi M (2000) The hyperphagic effect of nociceptin/orphanin FQ in rats. Peptides 21:1051–1062

    Article  CAS  PubMed  Google Scholar 

  • Qi W, Ding D, Salvi RJ (2008) Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures. Hear Res 236:52–60. doi:10.1016/j.heares.2007.12.002

    Article  CAS  PubMed  Google Scholar 

  • Roozendaal B, Lengvilas R, McGaugh JL, Civelli O, Reinscheid RK (2007) Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidation. Learn Mem 14:29–35

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roozendaal B, Schelling G, McGaugh JL (2008) Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the β-adrenoceptor–cAMP pathway: dependence on glucocorticoid receptor activation. J Neurosci 28(26):6642–6651

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saito ES, Kaiya H, Tachibana T, Tomonaga S, Denbow DM, Kangawa K, Furuse M (2005) Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul Pept 125:201–208

    Article  CAS  PubMed  Google Scholar 

  • Siniscalchi A, Rodi D, Morari M, Marti M, Cavallini S, Marino S, Beani L, Bianchi C (2002) Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro. Br J Pharmacol 136:1178–1184

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tachibana T, Sugahara K, Ueda H, Cline MA (2009) Role of adrenergic alpha-2-receptors on feeding behavior in layer-type chicks. Gen Comp Endocrinol 161:407–411

    Article  CAS  PubMed  Google Scholar 

  • Tajalli S, Jonaidi H, Abbasnejad M, Denbow DM (2006) Interaction between nociceptin/orphanin FQ (N/OFQ) and GABA in response to feeding. Physiol Behav 89:410–413

    Article  CAS  PubMed  Google Scholar 

  • Tsujii S, Bray GA (1998) A beta-3 adrenergic agonist (BRL-37,344) decreases food intake. Physiol Behav 63:723–728

    Article  CAS  PubMed  Google Scholar 

  • Van Tienhoven A, Juhasz LP (1962) The chicken telencephalon, diencephalon and mesencephalon in sterotaxic coordinates. J Comp Neurol 118:185–197

    Article  Google Scholar 

  • Wellman PJ (1992) Overview of adrenergic anorectic agents. Am J Clin Nutr 55(1):193S–198S

    CAS  PubMed  Google Scholar 

  • Wellman PJ, Davis BT, Morien A, McMahon L (1993) Modulation of feeding by hypothalamic paraventricular nucleus α1- and α2-adrenergic receptors. Life Sci 53:669–679

    Article  CAS  PubMed  Google Scholar 

  • Werthwein S, Bauer U, Nakazi M, Kathmann M, Schlicker E (1999) Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro. Br J Pharmacol 127:300–308

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zendehdel M, Ghashghayi E, Hassanpour S, Baghbanzadeh A, Jonaidi H (2016) Interaction between opioidergic and dopaminergic systems on food intake in neonatal layer type chicken. Int J Pept Res Ther 22:83–92

    Article  CAS  Google Scholar 

  • Zendehdel M, Hamidi F, Hassanpour S (2015) The effect of histaminergic system on nociceptin/orphanin FQ induced food intake in chicken. Int J Pept Res Ther 21:179–186

    Article  CAS  Google Scholar 

  • Zendehdel M, Hassanpour S (2014) Ghrelin-induced hypophagia is mediated by the β2 adrenergic receptor in chicken. J Physiol Sci 64:383–391

    Article  CAS  PubMed  Google Scholar 

  • Zendehdel M, Mokhtarpouriani K, Babapour V, Baghbanzadeh A, Pourrahimi M, Hassanpour S (2013) The effect of serotonergic system on nociceptin/orphanin FQ induced food intake in chicken. J Physiol Sci 63:271–277

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This research was supported by a grant from the Research Council of the Faculty of Veterinary Medicine, University of Tehran, Iran.

Author information

Authors and Affiliations

  1. Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, PO Box 14155-6453, Tehran, Iran

    Morteza Zendehdel, Zahra Parvizi & Ali Baghbanzadeh

  2. Section of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Shahin Hassanpour

  3. Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

    Farshid Hamidi

Authors
  1. Morteza Zendehdel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zahra Parvizi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shahin Hassanpour
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ali Baghbanzadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Farshid Hamidi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Morteza Zendehdel.

Ethics declarations

Conflict of Interest

Morteza Zendehdel, Zahra Parvizi, Shahin Hassanpour, Ali Baghbanzadeh and Farshid Hamidi declare that they have no conflict of interest.

Informed Consent

This manuscript does not contain any studies with human subjects performed by any of the authors.

Human and Animal Rights

All experiments executed according to the Guide for the Care and Use of Laboratory Animals and approved by the Institutional Animal Ethics Committee.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zendehdel, M., Parvizi, Z., Hassanpour, S. et al. Interaction Between Nociceptin/Orphanin FQ and Adrenergic System on Food Intake in Neonatal Chicken. Int J Pept Res Ther 23, 155–161 (2017). https://doi.org/10.1007/s10989-016-9548-2

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10989-016-9548-2

Keywords

Search

Navigation