Skip to main content
SpringerLink
Log in

Vitamin A and vitamin E interaction behavior on chitosan microspheres

A calorimetric view

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

Chitosan is a biodegradable natural polymer with great potential for pharmaceutical applications due to its biocompatibility, high charge density, and non-toxicity. In this study, chitosan microspheres were successfully prepared by an adapted method of coagulation/dispersion. The degree of deacetylation of chitosan powder was obtained by NMR 1H and FTIR techniques. Chitosan powder and chitosan microspheres were characterized by BET surface area and scanning electron microscopy (SEM). The interactions among the chitosan microspheres and the vitamins A and E were characterized by FTIR. In order to evaluate the ability of interaction of vitamin A and vitamin E with the chitosan microspheres, the thermodynamic parameters were followed by calorimetric titration. Different experimental approaches were applied, such as adsorption isotherms, kinetics and thermodynamics studies. The obtained results showed that the interactions of chitosan microspheres with the vitamins were spontaneous, enthalpically and entropically favorable, indicating that the chitosan microspheres can be used with success in the controlled release of these vitamins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Disponível em: http://www.abihpec.org.br. Accessed 26 Fev 2010.

  2. Manela-Azulay M, Bagatin E. Cosmeceuticals vitamins. Clin Dermatol. 2009;27:469–74.

    Article  Google Scholar 

  3. Gao XH, Li Z, Wei H, Chen HD. Efficacy and safety of innovative cosmeceuticals. Clin Dermatol. 2008;26:367–74.

    Article  Google Scholar 

  4. Oblong JE, Bisset DL. Retinoids. In: Draelos ZD, editor. Cosmeceuticals. 1st ed. Philadelphia: Elsevier Saunders; 2005. p. 35–45.

    Google Scholar 

  5. Darvin M, Zastriw L, Sterry W, Lademann J. Effect of supplemented and topically applied antioxidant substances on human tissue. Skin Pharmacol Appl Skin Physiol. 2006;19:238–47.

    CAS  Google Scholar 

  6. Sabliov CM, Fronczek C, Astete CE, Khachaturyan M, Khachatryan L, Leonardi C. Effects of temperature and UV light on degradation of α-tocopherol in free and dissolved form. J Am Oil Chem Soc. 2009;86:895–902.

    Article  CAS  Google Scholar 

  7. Lehman PA, Slattery JT, Franz TJ. Percutaneous absorption of retinoids, influence on vehicle, light exposure and dose. J Invest Dermatol. 1988;91:56–61.

    Article  CAS  Google Scholar 

  8. Berkland C, Kim KK, Pack DW. Fabrication of PLGA microspheres with precisely controlled and nanodisperse size distribution. J Controlled Release. 2001;73(1):58–74.

    Article  Google Scholar 

  9. Dinarvand R, Rahmani E, Farbod E. Gelatin microspheres for the controlled release of all-trans-retinoic acid topical formulation and drug delivery evaluation. Int J Pharm Res. 2003;2:47–50.

    CAS  Google Scholar 

  10. Rorrer GL, Hsein TY, Way JD. Synthesis of porous-magnetic chitosan beads for removal of cadmium ions from wastewater. Ind Eng Chem Res. 1993;32:2170–8.

    Article  CAS  Google Scholar 

  11. Prado AGS, Pescara IC, Albuquerque RDA, Honorato FN, Almeida CM. Sistema de baixo custo para produção de microesferas de quitosana. Analytica. 2010;44:62–7.

    Google Scholar 

  12. Signini R, Campana Filho SP. On the preparation and characterization of chitosan hydrochloride. Polym Bull. 1999;42:159–66.

    Article  CAS  Google Scholar 

  13. Prado AGS, Macedo JL, Dias SCL, Dias JA. Calorimetric studies of association of chitin and chitosan with sodium dodecyl sulfate. Colloids Surf B. 2004;35:23–7.

    Article  CAS  Google Scholar 

  14. Prado AGS, Moura AO, Andrade RDA, Pescara IC, Ferreira VS, Faria EA, Oliveira AHA, Okino EYA, Zara LF. Application of Brazilian sawdust samples for chromium removal from tannery wastewater. J Therm Anal Calorim. 2010;99:681–7.

    Article  CAS  Google Scholar 

  15. Prado AGS, Torres JD, Faria EA, Dias SCL. Comparative adsorption studies of indigo carmine dye on chitin and chitosan. J Colloid Interface Sci. 2004;277:43–7.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors acknowledge the financial support and fellowships by FAP-DF, CNPq and CAPES-REUNI.

Author information

Authors and Affiliations

  1. QuiCSI Team, Institute of Chemistry, University of Brasilia, C.P. 4478, Brasilia, DF, 70904-970, Brazil

    Alexandre G. S. Prado, André L. F. Santos, Carolina P. Pedroso, Thiago O. Carvalho, Lilian R. Braga & Sheila M. Evangelista

Authors
  1. Alexandre G. S. Prado
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. André L. F. Santos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carolina P. Pedroso
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Thiago O. Carvalho
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lilian R. Braga
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sheila M. Evangelista
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alexandre G. S. Prado.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Prado, A.G.S., Santos, A.L.F., Pedroso, C.P. et al. Vitamin A and vitamin E interaction behavior on chitosan microspheres. J Therm Anal Calorim 106, 415–420 (2011). https://doi.org/10.1007/s10973-011-1418-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10973-011-1418-8

Keywords

Search

Navigation