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Encapsulation and characterization of flurbiprofen loaded poly(є-caprolactone)–poly(vinylpyrrolidone) blend micropheres by solvent evaporation method

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Abstract

Flurbiprofen loaded PCL/PVP blend microspheres were prepared by o/w solvent evaporation method using various concentrations of gelatin as emulsifying agent. Microsphere recovery decreased with a decrease in the concentration of the emulsifier in the dispersion. Encapsulation efficiency and drug loading of microspheres increased with decrease in concentration of emulsifying agent. Hydration rate, encapsulation efficiency and drug loading of microspheres increased with increase in concentration of PVP. Rheological properties showed free flowing nature of microspheres. SEM (Scanning electron microscope) revealed microspheres were discrete, spherical and became porous with decrease in concentration of emulsifying agent but smooth with higher concentration of emulsifying agent. FTIR (Fourier transform infrared spectroscopy) spectra of pure and encapsulated flurbiprofen in all formulation showed no significant difference in characteristic peaks, suggesting stability of flurbiprofen during encapsulation process. X-RD (X-ray powder diffractometry) of pure flurbiprofen shows sharp peaks, which decreases on encapsulation, indicating dispersion at molecular level and hence decrease in the crystallinity of drug in microspheres. Microspheres showed an enteric nature at pH 1.2 and a sustained release pattern at pH 6.8. Rapid drug release was observed in microspheres with higher concentration of PVP (polyvinylpyrrolidone), PVP acts as channeling agent. Formulation with low concentration of emulsifying agent also showed a fast release due to porous structure. Drug release kinetics followed zero order at pH 1.2 while at pH 6.8 Higuchi model was best fitted and was found non fickian.

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References

  1. Nokhodchi A, Farid D (2002) Pharm Technol 26:54–60

    Google Scholar 

  2. Bi-Botti C, Youan, Hussain A, Nguyen NT (2003) AAPS PharmSci 5(2):123–131, Article 22

  3. Mathew ST, Devi SG, Sandhya KV (2007) AAPS PharmSci 8(1):14

    Google Scholar 

  4. Ohmukai O (1996) Adv Drug Deliv Rev 20:203–207

    Article  CAS  Google Scholar 

  5. Fang JY, Leu YL, Chang CC, Lin CH, Tsai YH (2004) Drug Deliv 11:97–105. doi:10.1080/10717540490280697

    Article  PubMed  CAS  Google Scholar 

  6. Kim BK, Hwang SJ, Park JB, Park HJ (2005) J Microencapsul 22:193–203. doi:10.1080/02652040400015346

    Article  PubMed  CAS  Google Scholar 

  7. Sinha VR, Bansal K, Kaushik R, Kumria R, Trehan A (2004) Int J Pharm 278:1–23. doi:10.1016/j.ijpharm.2004.01.044

    Article  PubMed  CAS  Google Scholar 

  8. Emeje MO, Kunle OO, Ofoefule SI (2006) AAPS PharmSciTech 7:E1–E4. doi:10.1208/pt070358

    Article  Google Scholar 

  9. Samati Y, Yuksel N, Tarimci N (2006) Drug Deliv 13:105–111. doi:10.1080/10717540500313331

    Article  PubMed  CAS  Google Scholar 

  10. Sah H (1997) J Control Rel 47:233–245. doi:10.1016/S0168-3659(97)01647-7

    Article  CAS  Google Scholar 

  11. Wang S, Guo S, Cheng L (2008) Int J Pharm 350:130–137. doi:10.1016/j.ijpharm.2007.08.030

    Article  PubMed  CAS  Google Scholar 

  12. Banker GS, Anderson NR (1987) Tablets. In: Lachmann L, Liberman HA, Kanig JL (eds) Theory and practice of industrial pharmacy. Lea and Febiger, Philadelphia, p 316

    Google Scholar 

  13. Shariff A, Manna PK, Paranjothy KLK, Manjula M (2007) Pak J Pharm Sci 20:1–9

    PubMed  CAS  Google Scholar 

  14. Najib N, Suleiman M (1985) Drug Dev Ind Pharm 11:2169–2189. doi:10.3109/03639048509087779

    Article  CAS  Google Scholar 

  15. Desai SJ, Singh P, Simonelli AP, Higuchi WI (1966) J Pharm Sci 55:1230–1234. doi:10.1002/jps.2600551113

    Article  PubMed  CAS  Google Scholar 

  16. Higuchi T (1963) Pharm Sci 50:1145–1149

    Article  Google Scholar 

  17. Hixon AW, Crowel JH (1931) Ind Eng Chem 23:923–931. doi:10.1021/ie50260a018

    Article  Google Scholar 

  18. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA (1983) Int J Pharm 15:25–35. doi:10.1016/0378-5173(83)90064-9

    Article  CAS  Google Scholar 

  19. Lai M-K, Tsiang RC-C (2004) J Microencapsul 21:307–316. doi:10.1080/02652040410001673928

    Article  PubMed  CAS  Google Scholar 

  20. Rosilio V, Costa M, Baszkin A (1998) J Dispersion Sci Technol 19:821–841. doi:10.1080/01932699808913217

    Article  CAS  Google Scholar 

  21. Sahoo SK, Mallick AA, Barik BB, Senapati PC (2005) Trop J Pharm Res 4:369–375

    Google Scholar 

  22. Paradkar A, Mahehwari M, Tyagi AK, Chauhan B, Kadam SS (2003) AAPS PharmSciTech 4:1–9. doi:10.1208/pt040465

    Article  Google Scholar 

  23. Babu VR, Reddy KM, Sairam M, Subha MCS, Mallikarjuna NN, Kulkarni PV, Aminabhavi TM (2007) Des Monomers Polymers 10:155–165. doi:10.1163/156855507780378276

    Article  CAS  Google Scholar 

  24. Jeong JC, Lee J, Cho K (2003) J Control Rel 92:249–258. doi:10.1016/S0168-3659(03)00367-5

    Article  CAS  Google Scholar 

  25. Assimopoulou AN, Papageorgiou VP (2004) J Microencapsul 21:161–173. doi:10.1080/02652040310001637839

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

    Nazar Mohammad Ranjha

  2. Faculty of Pharmacy, Government College University, Faisalabad, Pakistan

    Ikram Ullah Khan

  3. Centre of Excellence in Solid State Physics, Punjab University, Lahore, Pakistan

    Shahzad Naseem

Authors
  1. Nazar Mohammad Ranjha
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  2. Ikram Ullah Khan
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  3. Shahzad Naseem
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Correspondence to Nazar Mohammad Ranjha.

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Ranjha, N.M., Khan, I.U. & Naseem, S. Encapsulation and characterization of flurbiprofen loaded poly(є-caprolactone)–poly(vinylpyrrolidone) blend micropheres by solvent evaporation method. J Sol-Gel Sci Technol 50, 281–289 (2009). https://doi.org/10.1007/s10971-009-1957-7

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  • DOI: https://doi.org/10.1007/s10971-009-1957-7

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