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Exploitation of Aspergillus flavus synthesized copper oxide nanoparticles as a novel medical agent

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Abstract

This study was designed to biosynthesize Aspergillus flavus copper oxide NPs (AFCuONPs) using extracellular fungous filtrate technique and evaluating its medical importance. AFCuONPs were successfully biosynthesized with average size of 32.4 nm and zeta potential of – 36 mV. They were fully characterized using FT-IR, UV–Vis spectrophotometry, and TEM. AFCuONPs cytotoxicity and bactericidal activity were evaluated against different cell lines and pathogenic bacteria, respectively. [99mTc]Tc-AFCuONPs were radiosynthesized with high radiolabeling yield (93 ± 0.85%). In vivo biodistribution of [99mTc]Tc-AFCuONPs in tumor-bearing mice model showed high tumor uptake. These results introduce AFCuONPs as a promising medical agent.

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Acknowledgements

Prof. Tamer M. Sakr expresses his grateful appreciation and thanks for International Atomic Energy Authority (IAEA) for international collaboration and funding this work under CRP No. F22064.

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Authors and Affiliations

  1. Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt

    Mohamed A. Amin & Samia M. Ayoub

  2. Regional Center for Mycology and Biotechnology, AL-Azhar University, Nasr City, Cairo, Egypt

    Mahmoud M. EL-Aasser

  3. Botany and Microbiology Department, Faculty of Science, AL-Azhar University, Nasr City, Cairo, Egypt

    Hessain H. EL- Shiekh

  4. Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt

    Tamer M. Sakr

  5. Radioisotopes Production Facility, Second Egyptian Research Reactor Complex, Egyptian Atomic Energy Authority, Cairo, 13759, Egypt

    Tamer M. Sakr

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  1. Mohamed A. Amin
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  2. Mahmoud M. EL-Aasser
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  4. Hessain H. EL- Shiekh
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Amin, M.A., EL-Aasser, M.M., Ayoub, S.M. et al. Exploitation of Aspergillus flavus synthesized copper oxide nanoparticles as a novel medical agent. J Radioanal Nucl Chem 328, 299–313 (2021). https://doi.org/10.1007/s10967-021-07637-8

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