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Assessment of reactor-produced 199Au as a promising theranostic radionuclide and subsequent separation from platinum target

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Abstract

Feasibility of 199Au production from neutron activated platinum and gold targets at the Egyptian Second Research Reactor was studied. A comparison between theoretical calculations and experimental measurements for the two targets was carried out. A radiochemical separation of 199Au from irradiated Pt target was achieved using chromatographic column packed with modified chabazite material with elution efficiency of 90 ± 0.54% based on the high separation factor between Au and other produced undesired radionuclides. Three quality control tests; radionuclidic, radiochemical and chemical purities were carried out on the eluted 199Au to ensure its safe application in nuclear medicine.

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Authors and Affiliations

  1. Analytical Chemistry and Control Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Abu Zaabal, Cairo, Egypt

    Mohamed F. Attallah

  2. Radioisotopes Production Facility (RPF), Second Research Reactor (ETRR-2) and Labeled Compounds Department, Hot Labs Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    Mohamed A. Gizawy & Hesham A. Shamsel-Din

  3. Atomic Reactors Department, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    Nader M. A. Mohamed

  4. Technology of Nuclear Fuel Department, Hot Laboratories Center, Atomic Energy Authority of Egypt, P.O. Box 13759, Abu Zaabal, Cairo, Egypt

    Amal M. I. Ali

Authors
  1. Mohamed F. Attallah
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  2. Mohamed A. Gizawy
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  3. Hesham A. Shamsel-Din
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  4. Nader M. A. Mohamed
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  5. Amal M. I. Ali
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Correspondence to Mohamed F. Attallah or Mohamed A. Gizawy.

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Attallah, M.F., Gizawy, M.A., Shamsel-Din, H.A. et al. Assessment of reactor-produced 199Au as a promising theranostic radionuclide and subsequent separation from platinum target. J Radioanal Nucl Chem 325, 447–452 (2020). https://doi.org/10.1007/s10967-020-07257-8

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  • DOI: https://doi.org/10.1007/s10967-020-07257-8

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