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GMP production of 68Ga-labelled DOTA-NOC on IBA Synthera

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Abstract

68Ga labelled peptides are increasingly being used clinically due to widespread availability of 68Ge/68Ga generators and their recognised importance in the diagnosis of neuroendocrine tumours. A simple and reproducible GMP-compliant process for labelling peptides with generator-produced 68Ga is crucial to meet current pharmaceutical requirements. Here, we describe the development of a cassette-based 68Ga-radiolabelling process using an automated commercial synthesizer coupled with a standard 68Ge/68Ga generator. The radiolabeled somatostatin analogue [68Ga]DOTA-NOC was successfully synthesized in about 30 min with 80.3 ± 3.20 % of decay corrected radiochemical yield. The process is easily adaptable to the labelling of other peptides such as DOTA-TOC or DOTA-TATE for diagnosis or therapy.

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Authors and Affiliations

  1. ICNAS - Institute for Nuclear Sciences Applied to Health, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal

    Vítor H. Alves, M. I. M. Prata, Antero J. Abrunhosa & Miguel Castelo-Branco

  2. IBILI - Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal

    M. I. M. Prata, Antero J. Abrunhosa & Miguel Castelo-Branco

Authors
  1. Vítor H. Alves
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  2. M. I. M. Prata
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  3. Antero J. Abrunhosa
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  4. Miguel Castelo-Branco
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Correspondence to Vítor H. Alves.

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Alves, V.H., Prata, M.I.M., Abrunhosa, A.J. et al. GMP production of 68Ga-labelled DOTA-NOC on IBA Synthera. J Radioanal Nucl Chem 305, 501–506 (2015). https://doi.org/10.1007/s10967-015-3989-5

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  • DOI: https://doi.org/10.1007/s10967-015-3989-5

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