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Biodistribution of 99mTc–2-aminoestrone-3-methyl ether as a potential radiotracer for inflammation imaging

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Abstract

Estrogens may have pro- and anti-inflammatory properties depending on the situation and the involved tissue. 2-Aminoestrone-3-methyl ether as an estrogenic derivative was prepared with a yield of 55 % and well characterized. 99mTc–2-aminoestrone-3-methyl ether radiotracer was synthesized to study its inflammatory binding specificity as a novel selective radiopharmaceutical for inflammation imaging. In-vivo biodistribution study of 99mTc–2-amino estrone-3-methyl ether complex in both bacterial infection and sterile inflammation showed high and rapid accumulation of 99mTc–2-aminoestrone-3-methyl ether complex at the site of sterile inflammation compared to bacterial infection sites (target-to-non target ratio equal to 4.12 ± 0.02). This high biological accumulation in inflamed cells suggests that 99mTc–2-aminoestrone-3-methyl ether complex may be suitable as a potential selective radiotracer able to image inflammatory sites.

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Acknowledgments

This research project was supported by a grant from the “Research Center of Female Scientific and Medical Colleges”, Deanship of Scientific Research, King Saud University.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Maha S. Al Mutairi, Nadia G. Haress & Wafaa A. Zaghary

  2. Labeled Compound Department, Hot Labs Center, Atomic Energy Authority, Cairo, 13759, Egypt

    Mohammed A. Motaleb

Authors
  1. Maha S. Al Mutairi
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  2. Mohammed A. Motaleb
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  3. Nadia G. Haress
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  4. Wafaa A. Zaghary
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Correspondence to Wafaa A. Zaghary.

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Al Mutairi, M.S., Motaleb, M.A., Haress, N.G. et al. Biodistribution of 99mTc–2-aminoestrone-3-methyl ether as a potential radiotracer for inflammation imaging. J Radioanal Nucl Chem 303, 237–244 (2015). https://doi.org/10.1007/s10967-014-3320-x

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  • DOI: https://doi.org/10.1007/s10967-014-3320-x

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