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The “One Source” cohort — evaluating the suitability of the human toenail as a manganese biomonitor

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Abstract

Numerous studies have demonstrated that the human toenail is a reliable biomonitor for the intake of Se and other elements. The objective of this study was to evaluate the use of the toenail as a biomonitor for Mn. Toenail specimens from One Source™ multivitamin users and matched controls were selected. Se was measured using established NAA methods, then Mn was measured via a new procedure. The Se results confirmed the accurate classification of the cohort. However, the nail did not show significant, positive response to Mn supplementation. We hypothesize that the persistence of exogenous Mn confounded the results.

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Authors and Affiliations

  1. University of Missouri Research Reactor, Columbia, MO, 65211, USA

    J. M. Guthrie, J. D. Brockman, J. S. Morris & J. D. Robertson

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  1. J. M. Guthrie
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  2. J. D. Brockman
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  3. J. S. Morris
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  4. J. D. Robertson
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Correspondence to J. M. Guthrie.

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Guthrie, J.M., Brockman, J.D., Morris, J.S. et al. The “One Source” cohort — evaluating the suitability of the human toenail as a manganese biomonitor. J Radioanal Nucl Chem 276, 41–47 (2008). https://doi.org/10.1007/s10967-007-0407-7

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  • DOI: https://doi.org/10.1007/s10967-007-0407-7

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