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A critical review of molecularly imprinted solid phase extraction technology

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Abstract

Solid phase extraction (SPE) plays an important role in chemical and biological analysis. Compared with liquid–liquid extraction, SPE has the advantages of low solvent consumption, high efficiency, low cost, convenient operation and short time-consuming. However, the adsorbent used in SPE usually shows poor selectivity. The molecularly imprinted polymers (MIPs), which is similar to the binding of antigen and antibody, has specific adsorption capability to the specific molecules. Using MIP as the adsorbent of SPE prepared molecularly imprinted solid phase extraction (MISPE), can significantly improve the selectivity of SPE. MISPE has been widely used in separation, enrichment, pretreatment and detection. In this review, various modes of MISPE are systematically introduced, including off-line MISPE, on-line MISPE, molecularly imprinted-dispersive SPE, molecularly imprinted-matrix solid phase dispersion and magnetic MISPE. In addition, the applications of MISPE in food safety, environmental monitoring, drug and biological samples analysis are also reviewed.

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Funding

This work was supported by the National Natural Science Foundation of China (21576295 and 21804143); Fundamental Research Funds for Central Universities of the Central South University (2020zzts064); and the Natural Science Foundation of Hunan Province (2020JJ4686 and 2019JJ50759).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P. R. China

    Qingqing Wan, Hui Liu, Zhiwei Deng, Jiaqi Bu, Tianhao Li, Yanjing Yang & Shian Zhong

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  1. Qingqing Wan
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  2. Hui Liu
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  3. Zhiwei Deng
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  5. Tianhao Li
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Correspondence to Yanjing Yang or Shian Zhong.

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Wan, Q., Liu, H., Deng, Z. et al. A critical review of molecularly imprinted solid phase extraction technology. J Polym Res 28, 401 (2021). https://doi.org/10.1007/s10965-021-02744-2

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