Abstract
Self-healing hydrogels which have magical self-healing properties have attracted much attention in recent years. Here, we prepared a self-healing hydrogel with biocompatibility and NaHCO3 degradability. The hydrogel is constructed from cross-linking of poly(N,N-dimethyl acrylamide-stat-4-formylphenyl acrylate) P(DMA-stat-FPA) by pectin achlydrazide (pectin-AH). This hydrogel has base labile phenolic bonds connection and acylhydrazone bonds, which made the hydrogel degradable in extremely mild base of NaHCO3 solution and showed self-healing property. At the same time, the pectin endowed the hydrogels with good biocompatibility and biodegradabilty. In addition, hydrogel has micro-porous structure and showed controlled drug release behavior. These excellent properties made this hydrogel very useful in biomedical fields such as tissue engineering, drug carriers and biosensors.
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References
Yang C, Suo Z (2018) Hydrogel ionotronics. Nat Rev Mater 3(6): 125–142
Unutulmazsoy Y, Merkle R, Rastegar I, Maier J, Mannhart J (2017) Research Update: Ionotronics for long-term data storage devices. APL Mater 5(4):042302
Fong DD, Ramanathan S (2017) Ionotronics. APL Mater 5(4):042201
Yang CH, Chen B, Zhou J, Chen YM, Suo Z (2016) Electroluminescence of Giant Stretchability. Adv Mater 28(22):4480–4484
Yuk H, Lu BY, Zhao XH (2019) Hydrogel bioelectronics. Chem Soc Rev 48(6):1642–1667
Zhou Y, Wan C, Yang Y, Yang H, Wang S, Dai Z, Ji K, Jiang H, Chen X, Long Y (2019) Highly Stretchable, Elastic, and Ionic Conductive Hydrogel for Artificial Soft Electronics. Adv Funct Mater 29(1):201806220
Joshi N, Yan J, Levy S et al (2018) Towards an arthritis flare-responsive drug delivery system. Nat Commun 9(1):1275
Chaikasem S, Abeynayaka A, Visvanathan C (2014) Effect of polyvinyl alcohol hydrogel as a biocarrier on volatile fatty acids production of a two-stage thermophilic anaerobic membrane bioreactor. Bioresource Technol 168:100–105
Sakoda M, Kaneko M, Ohta S, Qi P, Ichimura S, Yatomi Y, Ito T (2018) Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel. Biomacromol 19(8):3280–3290
V. S, S. A, M. Annapoorna, J. R, I. Subramania, V.N. Shantikumar, J. R, (2018) Injectable deferoxamine nanoparticles loaded chitosan-hyaluronic acid coacervate hydrogel for therapeutic angiogenesis, Colloids Surf. B Biointerfaces 161:129–138
Larraneta E, Henry M, Irwin NJ, Trotter J, Perminova A, Donnelly RF (2018) Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications. Carbohyd Polym 181:1194–1205
Qu J, Zhao X, Liang Y, Zhang T, Ma PX, Guo B (2018) Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing. Biomaterials 183:185–199
Hamedi H, Moradi S, Hudson SM, Tonelli AE (2018) Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review. Carbohyd Polym 199:445–460
Naahidi S, Jafari M, Logan M, Wang Y, Yuan Y, Bae H, Dixon B, Chen P (2017) Biocompatibility of hydrogel-based scaffolds for tissue engineering applications. Biotechn Adv 35(5):530–544
Li J, Ma J, Chen S, He J, Huang Y (2018) Characterization of calcium alginate/deacetylated konjac glucomannan blend films prepared by Ca2+ crosslinking and deacetylation. Food Hydrocolloid 82:363–369
Hu ZH, Omer AM, Ouyang XK, Yu D (2018) Fabrication of carboxylated cellulose nanocrystal/sodium alginate hydrogel beads for adsorption of Pb (II) from aqueous solution. Int J Biol Macromolecules 108:149–157
Pawar SN, Edgar KJ (2012) Alginate derivatization: A review of chemistry, properties and applications. Biomaterials 33(11):3279–3305
Ma L, Chen S, Wang D, Yang Q, Mo F, Liang G, Li N, Zhang H, Zapien JA, Zhi C (2019) Super-Stretchable Zinc Air Batteries Based on an Alkaline-Tolerant Dual-Network Hydrogel Electrolyte. Adv Energy Mater 9(12):1803046
Melo BC, Paulino FA, Cardoso VA, Pereira AGB, Fajardo AR, Rodrigues FHA (2018) Cellulose nanowhiskers improve the methylene blue adsorption capacity of chitosan-g-poly (acrylic acid) hydrogel. Carbohyd Polym 181:358–367
Ali A, Ahmed S (2018) A review on chitosan and its nanocomposites in drug delivery. Int J Biological Macromolecules 109:273–286
Karmakar M, Mondal H, Mahapatra M, Chattopadhyay PK, Chatterjee S, Singha NR (2019) Pectin-grafted terpolymer superabsorbent via N-H activated strategic protrusion of monomer for removals of Cd (II), Hg (II), and Pb (II). Carbohyd Polym 206:778–791
Wang X, Chen Q, Lu X (2014) Pectin extracted from apple pomace and citrus peel by subcritical water. Food Hydrocolloid 38:129–137
Alvarez-Lorenzo C, Blanco-Fernandez B, Puga AM, Concheiro A (2013) Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery. Adv Drug Deliv Re 65(9):1148–1171
McClements DJ, Decker EA, Park Y, Weiss J (2009) Structural Design Principles for Delivery of Bioactive Components in Nutraceuticals and Functional Foods. Crit Rev Food Sci Nutrition 49(6):577–606
Vazquez-Gonzalez M, Willner I (2020) Stimuli-responsive Biomolecule-based Hydrogels and their Applications. Angew Chem Int Edit 59(36):15342–15377
Gan D, Xing W, Jiang L, Fang J, Zhao C, Ren F, Fang L, Wang K, Lu X (2019) Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry. Nat Commun 10(1):1487
Fu J, M. in het Panhuis, (2019) Hydrogel properties and applications. J Mater Chem B 7(10):1523–1525
Xiao X, Xie T, Cheng YT (2010) Self-healable graphene polymer composites. J Mater Chem 20(17):3508–3514
Karimi AR, Khodadadi A (2016) Mechanically Robust 3D Nanostructure Chitosan-Based Hydrogels with Autonomic Self-Healing Properties. ACS Appl Mater Interf 8(40):27254–27263
Han L, Yan L, Wang K, Fang L, Zhang H, Tang Y, Ding Y, Weng LT, Xu J, Weng J, Liu Y, Ren F, Lu X (2017) Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality. NPG Asia Mater 9(4):e372
Chang R, Wang X, Li X, An H, Qin J (2016) Self-Activated Healable Hydrogels with Reversible Temperature Responsiveness. ACS Appl Mater Interf 8(38):25544–25551
Deng G, Tang C, Li F, Jiang H, Chen Y (2010) Covalent Cross-Linked Polymer Gels with Reversible Sol−Gel Transition and Self-Healing Properties. Macromolecules 43(3):1191–1194
An H, Zhu L, Shen J, Li W, Wang Y, Qin J (2020) Self-healing PEG-poly (aspartic acid) hydrogel with rapid shape recovery and drug release. Colloids Surfaces B: Biointerfaces 185(1):110601
Hoffman MD, Benoit DSW (2015) Agonism of Wnt-β-catenin signalling promotes mesenchymal stem cell (MSC) expansion. J Tissue Eng Regen Medicine 9(11):E13–E26
He X, Yang X, Jabbari E (2012) Combined Effect of Osteopontin and BMP-2 Derived Peptides Grafted to an Adhesive Hydrogel on Osteogenic and Vasculogenic Differentiation of Marrow Stromal Cells. Langmuir 28(12):5387–5397
Hu X, Li H, Luo S, Liu T, Jiang Y, Liu S (2013) Thiol and pH dual-responsive dynamic covalent shell cross-linked micelles for triggered release of chemotherapeutic drugs. Polym Chem 4(3):695–706
Jivan F, Alge DL (2019) Bio-Orthogonal, Site-Selective Conjugation of Recombinant Proteins to Microporous Annealed Particle Hydrogels for Tissue Engineering. Adv Therap 3(1):1900148
Wu SW, Liu X, Miller AL II, Cheng YS, Yeh ML, Lu L (2018) Strengthening injectable thermo-sensitive NIPAAm-g-chitosan hydrogels using chemical cross-linking of disulfide bonds as scaffolds for tissue engineering. Carbohyd Polym 192:308–316
Perez-San Vicente A, Peroglio M, Ernst M, Casuso P, Loinaz I, Grande H-J, Alini M, Eglin D, Dupin D (2017) Self-Healing Dynamic Hydrogel as Injectable Shock-Absorbing Artificial Nucleus Pulposus. Biomacromol 18(8):2360–2370
Song KH, Highley CB, Rouff A, Burdick JA (2018) Complex 3D-Printed Microchannels within Cell-Degradable Hydrogels. Adv Funct Mater 28(31):1801331
Chen Y, Diaz-Dussan D, Wu D, Wang W, Peng Y-Y, Asha AB, Hall DG, Ishihara K, Narain R (2018) Bioinspired Self-Healing Hydrogel Based on Benzoxaborole-Catechol Dynamic Covalent Chemistry for 3D Cell Encapsulation. ACS Macro Lett 7(8):904–908
Zhao L, Niu L, Liang H, Tan H, Liu C, Zhu F (2017) pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing. ACS Appl Mater Interfaces 9(43):37563–37574
Bilal M, Rasheed T, Zhao Y, Iqbal HMN (2019) Agarose-chitosan hydrogel-immobilized horseradish peroxidase with sustainable bio-catalytic and dye degradation properties. Int J Biol Macromol 124:742–749
He K, Chen G, Zeng G, Chen A, Huang Z, Shi J, Huang T, Peng M, Hu L (2018) Three-dimensional graphene supported catalysts for organic dyes degradation. Appl Catal B: Environ 228:19–28
An H, Xu K, Chang L, Wang Y, Qin J, Li W (2018) Thermo-responsive self-healable hydrogels with extremely mild base degradability and bio-compatibility. Polymer 147:38–47
Chang R, An H, Li X, Zhou R, Qin J, Tian Y, Deng K (2017) Self-healable polymer gels with multi-responsiveness of gel-sol-gel transition and degradability. Polym Chem 8(7):1263–1271
Wu L, McHale R, Feng G, Wang X (2011) RAFT Synthesis and Self-Assembly of Free-Base Porphyrin Cored Star Polymers. Int J Polym Sci 2011:2341–2348
An H, Chang L, Shen J, Zhao S, Zhao M, Wang X, Qin J (2019) Light emitting self-healable hydrogel with bio-degradability prepared form pectin and Tetraphenylethylene bearing polymer. J Polym Res 26(2):26
Acknowledgements
This research was funded by the National Natural Science Foundation of China (51673016), Natural Science Foundation of Hebei Province (B2018201140), Program of Excellent Innovative Talents in Hebei Provincial Institution of Higher Education (No. SLRC2017048), Jiangsu Key Laboratory of Advanced Functional Polymers Design and Application, Soochow University (KJS2008) and State Key Laboratory of Organic-Inorganic Composites (oic-202001005).
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Chen, D., Chang, L., Zhou, Z. et al. Pectin-based self-healing hydrogel with NaHCO3 degradability for drug loading and release. J Polym Res 28, 59 (2021). https://doi.org/10.1007/s10965-021-02430-3
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DOI: https://doi.org/10.1007/s10965-021-02430-3