Skip to main content
Log in

The contribution of university research to the growth of academic start-ups: an empirical analysis

  • Published:
The Journal of Technology Transfer Aims and scope Submit manuscript

Abstract

The aim of this paper is to analyze empirically under which circumstances the universities located in a geographical area contribute to the growth of a special category of local new technology-based firms (NTBFs), those established by academic personnel (academic start-ups, ASUs). We examine the effects of a series of characteristics of local universities on the growth rates of ASUs and we compare them with the effects of the same university characteristics on the growth of other (i.e., non-academic) NTBFs. In the empirical part of the paper, we estimate an augmented Gibrat law panel data model using a longitudinal dataset composed of 487 Italian NTBFs observed from 1994 to 2003. Out of these NTBFs 48 are ASUs. The results of the econometric estimates suggest that universities do influence the growth rates of local ASUs, while the effects on the growth rates of other NTBFs are negligible. In particular, the scientific quality of the research performed by universities has a positive effect on the growth rates of ASUs; conversely the commercial orientation of research has a negative effect. These results indicate that universities producing high-quality scientific research have a beneficial impact on the growth of local high-tech start-ups, but only if these firms are able to detect, absorb, and use this knowledge. In this perspective, a greater commercial orientation of university research leading to a reduction of the knowledge available for absorption by these companies, can be detrimental.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Notes

  1. Researchers are defined as individuals who perform research activities in public research organizations, regardless of the contractual link with the parent institution. They include the research staff of parent organizations (both full time and part time) and also Ph.D. students.

  2. It is fair to acknowledge that, following the extant literature, we may expect a number of traits of universities additional to those analyzed in this paper to influence the growth potential of local NTBFs. In particular, prior studies have shown that university policies regarding intellectual property, licensing strategies and characteristics of technology transfer offices may affect university-to-industry knowledge transfer (for a review of these studies see again Agrawal 2001). Hence, we may expect these characteristics to influence firms’ growth potential too; however we decided not to consider them in this work. In Italy policies and support infrastructures for technology transfer have started spreading after 2000 and have proliferated only in the last couple of years. Therefore, very few universities already exhibited such properties over the period 1994–2003 that we consider in this work. As a consequence, we could not capture the effect of these characteristics through the estimation of econometric models over this time horizon. Thus we excluded the study of these characteristics from both the empirical analysis and the development of the theoretical hypotheses.

  3. Unfortunately, data provided by official national statistics do not allow to obtain a reliable description of the universe of Italian NTBFs. The main problem is that in Italy most individuals who are defined as “self-employed” by official statistics actually are salaried workers with atypical employment contracts. Unfortunately, on the basis of official data such individuals cannot be distinguished from entrepreneurs who created a new firm.

  4. Note that for only three firms the set of owner-managers at survey date did not include at least one of the founders of the firm. For these firms information relating to the human capital characteristics of the founders was checked through interviews with firms’ personnel so as to be sure that it did not relate to current owner-managers.

  5. Following prior studies on the Italian case (Piergiovanni et al. 1997; Rodríguez-Pose and Refolo 2003) we use the province as the geographic unit of analysis. Although some of the largest Italian universities have campuses in different provinces (for instance, Politecnico di Milano has six campuses over the Lombardy region in five provinces and one campus in Emilia Romagna), in Table 2 for each university we consider the location of the main campus only. This allows us be consistent with the data reported in the following. In fact, all the data on the characteristics of Italian universities are available at university level only (i.e., they are not disaggregated by provinces). Hence, in order to measure the number of researchers, the quality of the knowledge produced and the commercial orientation of local universities for Italian provinces, for each university we have attributed all the researchers and, coherently, all the research activities to the main campus. As faculty members are mainly located in the main campus, this approximation can be considered reasonably accurate.

  6. In particular, considering LSize i,t−1 as endogenous implies the use of instruments dated t−3 for the equation in first differences and instruments dated t−2 for the equation in level.

  7. The economic faculties include economics, management, and political sciences, while the technical faculties are engineering, chemistry, physics, geology, mathematics, biology, medicine, pharmaceutics, and computer science.

  8. The first available data on the amount of financing of Italian universities refer to the fiscal year 2000. In fact, it was only in 2001 that the National Committee for the Evaluation of the Academic System (Comitato Nazionale per la Valutazione del Sistema Universitario, CNVSU) started collecting the financial accounts of Italian universities and making available aggregated data. The reports of the CNVSU on the fiscal years 2000 and 2001 classified the revenues of Italian universities in three categories: financing from MIUR (the Italian Ministry of University and Research), university internal funds and financing from external sources. Since the publication of the report on the fiscal year 2002, three subcategories have been distinguished within the “external sources” category: financing from the European Union, from other public research organizations and from other organizations. As we are interested in the share of research funded by the private sector, we have to focus on the last subcategory. Hence, in calculating %PrivateBudget, we could not use data on the fiscal years 2000 and 2001. Note that the category “financing from other organizations” includes both financing from firms and financing from other sources (e.g., foundations). However, the role of foundations in financing academic research in Italy was fairly limited in the observation period. Hence, even though %PrivateBudget is likely to overestimate financing from firms, absent more fine grained data, it can be considered as a reasonably good proxy.

  9. %PrivateBudget was calculated as the average value over two subsequent years in order to reduce random fluctuations. We are aware that this variable, being time-invariant, might generate biases that may distort the estimates. In particular, as financing to universities from the Italian Central Government has decreased during the last decade, universities have started looking for additional sources of income thus probably raising the share of funds from private sources out of the total budget. This increase might have been more relevant for northern provinces as the industrial system of this area is more developed and local companies are likely to be more prone to finance academic research. Therefore, our measure of %PrivateBudget might overestimate the commercial orientation of universities located in northern provinces in the first years of the period under scrutiny. As a consequence, if in this period the growth rates of NTBFs located in northern provinces were higher (lower) than those of the companies located elsewhere because of unobserved effects, the estimates of the coefficient of %PrivateBudget might reveal a upward (downward) bias.

  10. In small family-owned Italian companies decision authority is often centralized in the owner-managers’ hands (see Colombo and Delmastro 1999), while salaried managers are assigned execution tasks. So, entrepreneurial learning associated with such managerial positions generally is fairly limited.

  11. We also controlled for other characteristics of the provinces where sample NTBFs are located, namely provincial deflated GDP per capita, provincial deflated GDP per capita rescaled on a national basis and provincial population or provincial density of population. The results are almost unchanged. They are available from the authors upon request.

  12. As we mentioned in footnote 6, GMM-SYS estimate requires the use of instruments for LSize i,t−1 , (LSize i,t−1 )2 and LSize i,t−1 ×LAge i,t−1 dated t−3 for the equation in first differences. Hence, the sample used for the estimates presented in Tables 5 and 6 excludes all RITA NTBFs for which data on size were available for less than three consecutive years.

  13. It is fair to acknowledge that 95 out of the 487 NTBFs included in our sample are located in provinces where there were no universities in the period under consideration. For these firms all the variables measuring the characteristics of local universities are always equal to zero over the time horizon 1994–2003. As a check for robustness, we reestimated the models using only the data on the 392 firms located in provinces where at least one university existed. The results are almost unchanged. They are available from the authors upon request.

  14. For a similar argument in a different context see Klepper (2007).

References

  • Acs, Z. J., Audretsch, D. B., & Feldman, M. P. (1992). Real effects of academic research. The American Economic Review, 82(1), 363–367.

    Google Scholar 

  • Acs, Z. J., Audretsch, D. B., & Feldman, M. P. (1994). R&D spillovers and recipient firm size. The Review of Economics and Statistics, 76(2), 336–340. doi:10.2307/2109888.

    Article  Google Scholar 

  • Agrawal, A. (2001). University-to-industry knowledge transfer: Literature review and unanswered questions. International Journal of Management Reviews, 3(4), 285–302. doi:10.1111/1468-2370.00069.

    Article  Google Scholar 

  • Aldrich, H. E., Kallenberg, A., Marsden, P., & Cassell, J. (1989). In pursuit of evidence: Sampling procedures for locating new businesses. Journal of Business Venturing, 4(6), 367–386. doi:10.1016/0883-9026(89)90008-6.

    Article  Google Scholar 

  • Anselin, L., Varga, A., & Acs, Z. J. (1997). Local geographic spillovers between University research and high technology innovations. Journal of Urban Economics, 42(3), 422–448. doi:10.1006/juec.1997.2032.

    Article  Google Scholar 

  • Arellano, M., & Bond, S. (1991). Some tests of specification for panel data: Monte Carlo evidence and an application to employment equations. The Review of Economic Studies, 58(2), 277–297. doi:10.2307/2297968.

    Article  Google Scholar 

  • Argyres, N. S., & Liebeskind, J. P. (1998). Privatizing the intellectual commons: Universities and the commercialization of biotechnology. Journal of Economic Behavior & Organization, 35(4), 427–454. doi:10.1016/S0167-2681(98)00049-3.

    Article  Google Scholar 

  • Arrow, K. (1962). Economic welfare and the allocation of resources for invention. In R. Nelson (Ed.), The rate and direction of inventive activity. Princeton, NJ: Princeton University Press.

    Google Scholar 

  • Audretsch, D. B., Keilbach, M., & Lehmann, E. E. (2005). Entrepreneurship and economic growth. London: Oxford University Press.

    Google Scholar 

  • Audretsch, D. B., & Lehmann, E. E. (2005a). Does the knowledge spillover theory of entrepreneurship hold for regions? Research Policy, 34(8), 1191–1202. doi:10.1016/j.respol.2005.03.012.

    Article  Google Scholar 

  • Audretsch, D. B., & Lehmann, E. E. (2005b). Mansfield’s missing link: The impact of knowledge spillovers on firm growth. The Journal of Technology Transfer, 30(1–2), 207–210. doi:10.1007/s10961-004-4367-6.

    Google Scholar 

  • Audretsch, D. B., & Lehmann, E. E. (2006). Entrepreneurial access and absorption of knowledge spillovers: Strategic board and managerial composition for competitive advantage. Journal of Small Business Management, 44(2), 155–166. doi:10.1111/j.1540-627X.2006.00161.x.

    Article  Google Scholar 

  • Audretsch, D. B., Lehmann, E. E., & Warning, S. (2004). University spillovers: Does the kind of knowledge matters? Industry and Innovation, 11(3), 193–205. doi:10.1080/1366271042000265375.

    Article  Google Scholar 

  • Audretsch, D. B., & Stephan, P. E. (1996). Company-scientist locational links: The case of biotechnology. The American Economic Review, 86(3), 641–652.

    Google Scholar 

  • Bade, F., & Nerlinger, E. A. (2000). The spatial distribution of new technology-based firms. Papers in Regional Science, 79(2), 155–176. doi:10.1007/s101100050041.

    Article  Google Scholar 

  • Barringer, B. R., Jones, F. F., & Neubaum, D. O. (2005). A quantitative content analysis of the characteristics of rapid-growth firms and their founders. Journal of Business Venturing, 20(5), 663–687. doi:10.1016/j.jbusvent.2004.03.004.

    Article  Google Scholar 

  • Bertoni, F., Colombo, M. G., & Grilli, L. (2007). Venture capital financing and the growth of new technology-based firms: A longitudinal analysis. Working paper.

  • Birley, S. (1984). Finding the new firm. Proceedings of the Academy of Management Meetings, 47, 64–68.

    Google Scholar 

  • Blundell, R., & Bond, S. (1998). Initial conditions and moment conditions in dynamic panel data models. Journal of Econometrics, 87(1), 115–143. doi:10.1016/S0304-4076(98)00009-8.

    Article  Google Scholar 

  • Bond, S. (2002). Dynamic panel data models: A guide to micro data methods and practice. Portuguese Economic Journal, 1(2), 141–162. doi:10.1007/s10258-002-0009-9.

    Article  Google Scholar 

  • Breno, E., Fava, G. A., Guardabasso, V., & Stefanelli, M. (2002). La ricerca scientifica nelle università italiane. Una prima analisi delle citazioni della banca dati ISI (Scientific research in Italian Universities. A first analysis of citations from ISI database). CRUI: Roma.

    Google Scholar 

  • Caves, R. (1998). Industrial organization and new findings on the turnover and mobility of firms. Journal of Economic Literature, 36(4), 1947–1982.

    Google Scholar 

  • Cockburn, I., & Henderson, R. (1998). Absorptive capacity, coauthoring behavior, and the organization of research in drug discovery. The Journal of Industrial Economics, 46(2), 157–182.

    Google Scholar 

  • Cohen, W. M., Florida, R., Randazzese, L., & Walsh, J. (1998). Industry and the academy: Uneasy partners in the cause of technological advance. In R. G. Noll (Ed.), Challenges to research universities (ch. 7). Washington, DC: Brookings Institute Press.

    Google Scholar 

  • Cohen, W. M., & Levinthal, D. A. (1989). Innovation and learning: The two faces of R&D. The Economic Journal, 99(397), 569–596. doi:10.2307/2233763.

    Article  Google Scholar 

  • Cohen, W. M., & Levinthal, D. A. (1990). Absorptive capacity: A new perspective on learning and innovation. Administrative Science Quarterly, 35(1), 128–152. doi:10.2307/2393553.

    Article  Google Scholar 

  • Colombo, M. G., & Delmastro, M. (1999). Some stylized facts on organisation and its evolution. Journal of Economic Behavior & Organization, 40(3), 252–274. doi:10.1016/S0167-2681(99)00067-0.

    Article  Google Scholar 

  • Colombo, M. G., & Grilli, L. (2005). Founders’ human capital and the growth of new technology-based firms: A competence-based view. Research Policy, 34(6), 795–816. doi:10.1016/j.respol.2005.03.010.

    Article  Google Scholar 

  • Colombo, M. G., & Piva, E. (2008a). Strenghts and weaknesses of academic start-ups: A conceptual model. IEEE Transactions on Engineering Management, 55(1), 37–49. doi:10.1109/TEM.2007.912807.

    Article  Google Scholar 

  • Colombo, M. G., & Piva, E. (2008b). Firms’ genetic characteristics, competence enlarging strategies and performances: A comparison between academic and non-academic high-tech start-ups. Working paper.

  • Dasgupta, P., & David, P. (1994). Towards a new economics of science. Research Policy, 23(5), 487–521. doi:10.1016/0048-7333(94)01002-1.

    Article  Google Scholar 

  • Del Barrio-Castro, T., & García-Quevedo, J. (2005). Effects of university research on the geography of innovation. Regional Studies, 39(9), 1217–1229. doi:10.1080/00343400500389992.

    Article  Google Scholar 

  • Di Gregorio, D., & Shane, S. (2003). Why do some universities generate more start-ups than others? Research Policy, 32(2), 209–227. doi:10.1016/S0048-7333(02)00097-5.

    Article  Google Scholar 

  • Drucker, J., & Goldstein, H. A. (2007). Assessing the regional economic development impacts of universities: A review of current approaches. International Regional Science Review, 30(1), 20–46. doi:10.1177/0160017606296731.

    Article  Google Scholar 

  • Evans, D. S. (1987a). The relationship between firm growth, size, and age: Estimates for 100 manufacturing industries. The Journal of Industrial Economics, 35(4), 567–581. doi:10.2307/2098588.

    Article  Google Scholar 

  • Evans, D. S. (1987b). Tests of alternative theories of firm growth. The Journal of Political Economy, 95(4), 657–674. doi:10.1086/261480.

    Article  Google Scholar 

  • Feeser, H. R., & Willard, G. E. (1990). Founding strategy and performance: A comparison of high and low growth high tech firms. Strategic Management Journal, 11(2), 87–98. doi:10.1002/smj.4250110202.

    Article  Google Scholar 

  • Feldman, M. P., & Florida, R. (1994). The geographic sources of innovation: Technological infrastructure and product innovation in the United States. Annals of the Association of American Geographers, 84(2), 210–229. doi:10.1111/j.1467-8306.1994.tb01735.x.

    Article  Google Scholar 

  • Fischer, E., & Reuber, R. (2003). Support for rapid growth firms: A comparison of the views of founders, government policy makers and private sector resource providers. Journal of Small Business Management, 41(4), 346–365.

    Article  Google Scholar 

  • Fischer, M. M., & Varga, A. (2003). Spatial knowledge spillovers and university research: Evidence from Austria. The Annals of Regional Science, 37(2), 303–322. doi:10.1007/s001680200115.

    Article  Google Scholar 

  • Gimeno, J., Folta, T., Cooper, A., & Woo, C. (1997). Survival of the fittest? Entrepreneurial human capital and the persistence of underperforming firms. Administrative Science Quarterly, 42(4), 750–783. doi:10.2307/2393656.

    Article  Google Scholar 

  • Goldstein, H. A., & Drucker, J. (2006). The economic development impacts of universities on regions: Do size and distance matter? Economic Development Quarterly, 20(1), 22–43. doi:10.1177/0891242405283387.

    Article  Google Scholar 

  • Goldstein, H. A., & Renault, C. S. (2004). Contributions of universities to regional economic development: A quasi-experimental approach. Regional Studies, 38(7), 733–746. doi:10.1080/0034340042000265232.

    Article  Google Scholar 

  • Hart, P. E., & Oulton, N. (1996). Growth and size of firms. The Economic Journal, 106(438), 1242–1252. doi:10.2307/2235518.

    Article  Google Scholar 

  • Jaffe, A. B. (1989). Real effects of academic research. The American Economic Review, 79(5), 957–970.

    Google Scholar 

  • Jaffe, A. B., Trajtenberg, M., & Henderson, R. (1993). Geographic localization of knowledge spillovers as evidenced by patent citations. The Quarterly Journal of Economics, 108(3), 577–598. doi:10.2307/2118401.

    Article  Google Scholar 

  • Klepper, S. (2007). Disagreements, spinoffs, and the evolution of Detroit as the capital of the U.S. automobile industry. Management Science, 53(4), 616–631. doi:10.1287/mnsc.1060.0683.

    Article  Google Scholar 

  • Lim, K. (2000). The many faces of absorptive capacity: Spillovers of copper interconnect technology for semiconductor chips. Mimeo: MIT.

    Google Scholar 

  • Little, A. D. (1977). New Technology-based firms in the United Kingdom and the federal Republic of Germany. London: Wilton House.

    Google Scholar 

  • Moulton, B. R. (1990). An illustration of a pitfall in estimating the effects of aggregate variables on micro units. The Review of Economics and Statistics, 72(2), 334–338. doi:10.2307/2109724.

    Article  Google Scholar 

  • Mowery, D. C., & Ziedonis, A. A. (2001). The geographic reach of market and non-market channels of technology transfer: Comparing citations and licenses of university patents. NBER Working Paper 8568.

  • Murray, F. (2004). The role of academic inventors in entrepreneurial firms: sharing the laboratory life. Research Policy, 33(4), 643–659. doi:10.1016/j.respol.2004.01.013.

    Article  Google Scholar 

  • Nelson, R. (1959). The simple economics of basic scientific research. The Journal of Political Economy, 67(3), 297–306. doi:10.1086/258177.

    Article  Google Scholar 

  • O’Shea, R. P., Allen, T. J., Chevalier, A., & Roche, F. (2005). Entrepreneurial orientation, technology transfer and spin-off performance of US universities. Research Policy, 34(7), 994–1009. doi:10.1016/j.respol.2005.05.011.

    Article  Google Scholar 

  • Piergiovanni, R., Santarelli, E., & Vivarelli, M. (1997). From which source do small firms derive their innovative inputs? Some evidence from Italian industry. Review of Industrial Organization, 12(2), 243–258. doi:10.1023/A:1007781501147.

    Article  Google Scholar 

  • Powers, J. B., & McDougall, P. P. (2005). University start-up formation and technology licensing with firms that go public: A resource-based view of academic entrepreneurship. Journal of Business Venturing, 20(3), 291–311. doi:10.1016/j.jbusvent.2003.12.008.

    Article  Google Scholar 

  • Roberts, E. B. (1991). High tech entrepreneurs: Lessons from MIT and beyond. New York: Oxford University Press.

    Google Scholar 

  • Roberts, E. B., & Malone, D. (1996). Policies and structures for spinning off new companies from research and development organizations. R & D Management, 26(1), 17–48. doi:10.1111/j.1467-9310.1996.tb00927.x.

    Article  Google Scholar 

  • Rodríguez-Pose, A., & Refolo, M. C. (2003). The link between local production systems and public and university research in Italy. Environment & Planning A, 35(8), 1477–1492. doi:10.1068/a35297.

    Article  Google Scholar 

  • Rosenberg, N., & Nelson, R. (1994). American universities and technical advance in industry. Research Policy, 23(3), 323–348. doi:10.1016/0048-7333(94)90042-6.

    Article  Google Scholar 

  • Stern, S. (2004). Do scientists pay to be scientists? Management Science, 50(6), 835–853. doi:10.1287/mnsc.1040.0241.

    Article  Google Scholar 

  • Storey, D. J. (1994). Understanding the small business sector. London: Thomson Learning.

    Google Scholar 

  • Stuart, T. E., Ozdemir, S. Z., & Ding, W. W. (2007). Vertical alliance networks: The case of university-biotechnology-pharmaceutical alliance chains. Research Policy, 36(4), 477–498. doi:10.1016/j.respol.2007.02.016.

    Article  Google Scholar 

  • Sutton, J. (1997). Gibrat’s legacy. Journal of Economic Literature, 35(1), 40–59.

    Google Scholar 

  • Varga, A. (2000). Local academic knowledge transfers and the concentration of economic activity. Journal of Regional Science, 40(2), 289–309. doi:10.1111/0022-4146.00175.

    Article  Google Scholar 

  • Wright, M., Birley, S., & Mosey, S. (2004). Entrepreneurship and university technology transfer. The Journal of Technology Transfer, 29(3–4), 235–246. doi:10.1023/B:JOTT.0000034121.02507.f3.

    Article  Google Scholar 

  • Zahra, S. A., & George, G. (2002). Absorptive capacity: A review, reconceptualization, and extension. Academy of Management Review, 27(2), 185–203. doi:10.2307/4134351.

    Article  Google Scholar 

  • Zucker, L. G., Darby, M. R., & Armstrong, J. S. (1998). Intellectual capital and the firm: The technology of geographically localized knowledge spillovers. Economic Inquiry, 36, 65–86.

    Article  Google Scholar 

  • Zucker, L. G., Darby, M. R., & Armstrong, J. S. (2000). University science, venture capital and the performance of U.S. biotechnology firms. Mimeo, Los Angeles: University of California.

    Google Scholar 

  • Zucker, L. G., Darby, M. R., & Brewer, M. (1999). Intellectual capital and the birth of U.S. biotechnology enterprises. The American Economic Review, 88(1), 290–306.

    Google Scholar 

Download references

Acknowledgments

Support from the REBASPINOFF project promoted by the PRIME Network of Excellence, the PICO project (“Academic entrepreneurship, from knowledge creation to knowledge diffusion”, contract n°028928) sponsored by the Sixth Framework Programme, the FIRB 2003 fund, the PRIN 2006 project 2006132439_002 and a grant from Unicredit is gratefully acknowledged. The authors would like to thank E. Rasmussen, A. Hughes, the participants in the XX RENT conference, and two anonymous referees for their useful comments.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Evila Piva.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Colombo, M.G., D’Adda, D. & Piva, E. The contribution of university research to the growth of academic start-ups: an empirical analysis. J Technol Transf 35, 113–140 (2010). https://doi.org/10.1007/s10961-009-9111-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10961-009-9111-9

Keywords

JEL Classification

Navigation