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Volumetric, Acoustic, Viscometric Properties, and Solute–Solvent Interactions of Metformin Hydrochloride in Aqueous Solution of Polyethylene Glycol (PEG 4000) at Different Temperatures (T = 288.15—318.15 K)

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Abstract

An attempt to understand the interactions between metformin, a drug, and a water-soluble polymer, polyethylene glycol (PEG 4000) in aqueous solutions through thermophysical and transport properties was made. The results are used to select the appropriate system for the separation or purification of biological material. In this paper, the thermodynamic and thermophysical data of the systems (water + PEG + metformin) are measured and reported for the first time. In this study, densities (ρ), speeds of sound (u) and viscosities (η) of aqueous solutions containing metformin within the molality range of (0–0.1) mol·kg−1 in aqueous solutions of PEG 4000 with different molality concentration of polymer, i.e., (0–0.1) mol·kg−1, at 288.15–318.15 K under atmospheric pressure (85 kPa) were measured. The apparent molar volume (Vϕ), limiting apparent molar volume (\(V_{\phi }^{0}\)), apparent molar isentropic compressibility (κφ) and limiting apparent molar isentropic compressibility (\(\kappa_{\phi }^{0}\)) were calculated from the experimental data. Also, transfer molar volume (\(\Delta_{{{\text{trans}}}} V_{\phi }^{0}\)), standard isentropic compressibility of transfer (\(\Delta_{{{\text{trans}}}} \kappa_{{_{\varphi } }}^{0}\)), and the transfer viscosity B-coefficients, \(\Delta_{{{\text{trans}}}} B\) for metformin–water as well as metformin–polymer–water have been studied, in addition to the limiting apparent molar expansibility (\(E_{\phi }^{0}\)). These quantities are useful for understanding the interactions between the solute and solvent in the ternary solutions of (water + metformin + PEG) due to changes made in their structures. The results indicated a favorable interaction and structure-making behavior of PEG. Moreover, the effect of temperature and metformin concentration on the viscosities of PEG aqueous solutions has been investigated.

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Authors and Affiliations

  1. Department of Chemical and Materials Engineering, Buein Zahra Technical University, Buein Zahra, Qazvin, Iran

    Fatemeh Arabgol

  2. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran

    Gholamreza Pazuki

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  1. Fatemeh Arabgol
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  2. Gholamreza Pazuki
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Correspondence to Fatemeh Arabgol.

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Supplementary file1 Fig. S-1 Variation of change in volume (RCV) values of the solutions with temperature (TIF 67 kb)

10953_2022_1181_MOESM2_ESM.tif

Supplementary file2 Fig. S-2 Raman spectroscopy for (a) binary system (water+ drug), (b) binary system (water + PEG), and (c) ternary system (water + PEG + drug) (TIF 415 kb)

Supplementary file3 (TIF 388 kb)

Supplementary file4 (TIF 401 kb)

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Arabgol, F., Pazuki, G. Volumetric, Acoustic, Viscometric Properties, and Solute–Solvent Interactions of Metformin Hydrochloride in Aqueous Solution of Polyethylene Glycol (PEG 4000) at Different Temperatures (T = 288.15—318.15 K). J Solution Chem 51, 1371–1392 (2022). https://doi.org/10.1007/s10953-022-01181-z

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