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Two compartmental fractional derivative model with general fractional derivative

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Abstract

This study presents a new two compartmental model with, recently defined General fractional derivative. We review that concept of General fractional derivative and use the kernel function that generalizes the classical Caputo derivative in a mathematically consistent way. Next we use this model to study the release of antibiotic gentamicin in poly (vinyl alcohol)/gentamicin(PVA/Gent) hydrogel aimed for wound dressing in medical treatment of deep chronical wounds. The PVA/Gent hydrogel was prepared by physical cross linking of poly (vinyl alcohol) dispersion using freezing–thawing method, and then was swollen in gentamicin solution at 37 °C during 48 h. The concentration of released gentamicin was determined using a high-performance liquid chromatography coupled with mass spectrometer. The advantage of this model is the existence of new parameters in the definition of fractional derivative, as compared with classical fractional compartmental models. The model proposed here in the special case reduces to the classical (integer order) linear two compartmental model as well as classical fractional order two compartmental model since it has more parameters that are determined from the experimental results.

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Acknowledgements

This research is supported by University Union—Nikola Tesla, Belgrade, Serbia (VMS) and Faculty of Technical Sciences, University of Novi Sad (TMA).

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Authors and Affiliations

  1. Faculty of Ecology and Environmental Protection, University Union - Nikola Tesla, Cara Dusana 62-64, 11000, Belgrade, Serbia

    Vesna Miskovic-Stankovic

  2. Mathematical Institute, Serbain Academy of Arts and Sciences, Kneza Mihaila 35, 11000, Belagrade Belgrade, Serbia

    Marko Janev

  3. Serbian Academy of Arts and Sciences, Branch in Novi Sad, Nikole Pasica 6, 21000, Novi Sad, Serbia

    Teodor M. Atanackovic

Authors
  1. Vesna Miskovic-Stankovic
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  3. Teodor M. Atanackovic
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Contributions

VMS was responsible for hydrogel preparation and wrote the main manuscript text. MJ performed the numerical analysis. TMA formulated the mathematical model and prepared figures. All authors reviewed the manuscript.

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Correspondence to Teodor M. Atanackovic.

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Miskovic-Stankovic, V., Janev, M. & Atanackovic, T.M. Two compartmental fractional derivative model with general fractional derivative. J Pharmacokinet Pharmacodyn 50, 79–87 (2023). https://doi.org/10.1007/s10928-022-09834-8

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  • DOI: https://doi.org/10.1007/s10928-022-09834-8

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