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Antibacterial Activity and Drug Release of Ciprofloxacin Loaded PVA-nHAp Nanocomposite Coating on Ti-6Al-4 V

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Abstract

Here, a new composite coating was introduced for the Ti-6Al-4 V implant, and the different properties were investigated in-vitro. For this purpose, the Hydroxyapatite nanopowder (nHAp) was synthesized, and the x-ray diffraction (XRD) pattern and field emission scanning electron microscopy (FE-SEM), energy-dispersive x-ray spectroscopy (EDX) evaluations confirmed the nHAp formation. Then Ti-6Al-4 V substrates were sandblasted, and the average surface roughness (Ra) was increased from 23.75 to 31.59 nm after sandblasting operation. Then, nHAp coating was applied on the surface by electrophoretic deposition. Ciprofloxacin (CIP), a common antibacterial drug, was loaded on some nHAp coating Ti substrates. In order to form a crack-free coating and improve biocompatibility, hydrophilicity, and controlled drug release, polyvinyl alcohol (PVA) coating was created on Ti substrates coated with CIP-nHAp. Different properties of non-coated Ti-6Al-4 V, nHAp coated Ti-6Al-4 V, and PVA-CIP coated Ti-6Al-4 V were examined. Fourier-transform infrared and XRD tests proved the presence of CIP on the substrates, and FESEM and EDX tests demonstrated the formation of a crack-free, approximately homogenous coating on all substrates. The drug release evaluation showed sustained CIP releasing with a diffusion mechanism. The antibacterial on both S. aureus and E. coli was higher for CIP-containing substrates than in other samples.

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Acknowledgements

This research was supported by the Materials and Energy Research Center under grant No. 771397055.

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Authors and Affiliations

  1. Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Iran

    Melika Hajinaebi & Monireh Ganjali

  2. Hormoz Research Center, Hormozgan University, Bandar Abbas, Iran

    Navid Ahmadi Nasab

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  1. Melika Hajinaebi
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  2. Monireh Ganjali
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  3. Navid Ahmadi Nasab
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Correspondence to Monireh Ganjali.

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Hajinaebi, M., Ganjali, M. & Nasab, N.A. Antibacterial Activity and Drug Release of Ciprofloxacin Loaded PVA-nHAp Nanocomposite Coating on Ti-6Al-4 V. J Inorg Organomet Polym 32, 3521–3532 (2022). https://doi.org/10.1007/s10904-022-02361-6

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  • DOI: https://doi.org/10.1007/s10904-022-02361-6

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