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Precise Construction of Injectable Bioactive Glass/Polyvinyl Alcohol Nanocomposite Hydrogels Promising to Repair the Shoulder Joint Head for Hemiarthroplasty

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Abstract

A physical cross-linking method was used to construct an injectable hydrogel composite comprised of bioactive glass (BG) particles and polyvinyl alcohol (PVA). BG/PVA hydrogel morphology, mechanical properties, and viscoelasticity were explored. The hydrogel composite had a homogeneous and uniform distribution of BG particles, as evidenced by scanning electronic microscopy. The elastic modulus and static compressive strength were elevated by 152% and 345%, respectively, by adding 2.5 wt% BG particles to the hydrogel composite constructions. A self-standing elastic hydrogel composite with a smooth injectability was found to have a storage mould (G) more remarkable than a loss module (G″) and over the entire frequency range examined. The cell viability and live/dead assay investigation suggested the suitability of the BG/PVA hydrogel composite compared to the control PVA hydrogel groups. Adult male rats were implanted subcutaneously with the BG/PVA hydrogel composite. No inflammatory cell was found inside or over the implant after 4 weeks of implantation, indicating that the hydrogel composite was highly biocompatible. The newly constructed injectable hydrogel BG/PVA nanocomposite properties establish its ability to repair the shoulder joint head for hemiarthroplasty.

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  1. Department of Trauma Orthopedics, the First People’s Hospital of Wenling, No.333, Chuanan South Road, Chengxi Street, Wenling, 317500, Zhejiang, China

    Fengping Li & Cong Lin

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Li, F., Lin, C. Precise Construction of Injectable Bioactive Glass/Polyvinyl Alcohol Nanocomposite Hydrogels Promising to Repair the Shoulder Joint Head for Hemiarthroplasty. J Clust Sci 34, 1841–1851 (2023). https://doi.org/10.1007/s10876-022-02331-5

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