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Antioxidant, Anti-inflammatory and Biosorption Properties of Starch Nanocrystals In Vitro Study: Cytotoxic and Phytotoxic Evaluation

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Abstract

This study aimed to investigate the antioxidant, anti-inflammatory and biosorption properties of starch nanocrystals (SNC). The characterization of synthesized SNC was done using various analytical techniques like microscopic and spectroscopic analysis. The antioxidant property was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and metal ion chelating assay. SNC showed the highest scavenging activity of 70.03 ± 0.74% at 100 µg/mL concentration. Protein denaturation assay and proteinase inhibitory assay depicted the anti-inflammatory property of SNC. The results revealed that the maximum inhibition activity was found at 100 µg/mL with 72.71% inhibition. The maximum removal efficiency was found to be 83.42% at pH 2.0 with 0.15 g biosorbent. As the pH increases, biosorption capacity of SNC were reduced from 8.17 to 6.30 mg/g and the efficiency of the dye removal was decreased from 80.95 to 36.01%. The shape of synthesized SNC was spherical nanoplatelets and it shows agglomeration. The Langmuir isotherm model is best suited for the biosorption experiments with the R2 value of 0.986. SNC were subjected to cytotoxic and phytotoxic evaluation. Cell viability and phytotoxic assays proves the non-toxic nature of the SNC.

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References

  1. S. Mishra, C. Keswani, P. C. Abhilash, L. F. Fraceto, and H. B. Singh (2017). Front. Plant Sci.8, 471.

    Google Scholar 

  2. S. Salari, S. Esmaeilzadeh Bahabadi, A. Samzadeh-Kermani, and F. Yousefzaei (2019). Iran. J. Pharm. Res.18, 430.

    PubMed  PubMed Central  CAS  Google Scholar 

  3. H. Barabadi, K. Damavandi Kamali, F. Jazayeri Shoushtari, B. Tajani, M. A. Mahjoub, A. Alizadeh, and M. Saravanan (2019). J. Clust. Sci.30, 1375.

    Article  CAS  Google Scholar 

  4. G. Benelli and C. M. Lukehart (2017). J. Clust. Sci.28, 1.

    Article  CAS  Google Scholar 

  5. H. Chen, S. Wageh, A. A. Al-Ghamdi, H. Wang, J. Yu, and C. Jiang (2019). J. Colloid Interface Sci.537, 736.

    Article  CAS  Google Scholar 

  6. V. K. Gupta, I. Ali, T. A. Saleh, A. Nayak, and S. Agarwal (2012). RSC Adv.2, 6380.

    Article  CAS  Google Scholar 

  7. C. Lei, M. Pi, D. Xu, C. Jiang, and B. Cheng (2017). Appl. Surf. Sci.426, 360.

    Article  CAS  Google Scholar 

  8. K. Cui, B. Yan, Y. Xie, H. Qian, X. Wang, Q. Huang, Y. He, S. Jin, and H. Zeng (2018). J. Hazard. Mater.350, 66.

    Article  CAS  Google Scholar 

  9. A. Waheed, M. Mansha, I. W. Kazi, and N. Ullah (2019). J. Hazard. Mater.369, 528.

    Article  CAS  Google Scholar 

  10. M. M. Galangash, Z. N. Kolkasaraei, A. Ghavidast, and M. Shirzad-Siboni (2016). RSC Adv.6, 113492.

    Article  CAS  Google Scholar 

  11. N. P. Raval, P. U. Shah, and N. K. Shah (2016). Environ. Sci. Pollut. Res.23, 14810.

    Article  CAS  Google Scholar 

  12. A. Mittal, J. Mittal, A. Malviya, and V. K. Gupta (2009). J. Colloid Interface Sci.340, 16.

    Article  CAS  Google Scholar 

  13. K. GZ, S. PI, P. EG, C. KJ, and B. DN (2015). Chem. Eng. J.259, 438.

    Article  CAS  Google Scholar 

  14. Q. Chang, M. Zhang, and J. Wang (2009). J. Hazard. Mater.169, 621.

    Article  CAS  Google Scholar 

  15. Y. Gilgun-Sherki, Z. Rosenbaum, E. Melamed, and D. Offen (2002). Pharmacol. Rev.54, 271.

    Article  CAS  Google Scholar 

  16. S. Veena, T. Devasena, S. S. M. Sathak, M. Yasasve, and L. A. Vishal (2019). J. Clust. Sci.30, 1591.

    Article  CAS  Google Scholar 

  17. K. D. P. P. Gunathilake, K. K. D. S. Ranaweera, and H. P. V. Rupasinghe (2018). Biomedicines6, 107.

    Article  CAS  Google Scholar 

  18. M. Haroon, L. Wang, H. Yu, N. M. Abbasi, Zain-ul-Abdin, M. Saleem, R. U. Khan, R. S. Ullah, Q. Chen, and J. Wu (2016). RSC Adv.6, 78264.

    Article  CAS  Google Scholar 

  19. X. Li, Y. Qin, C. Liu, S. Jiang, L. Xiong, and Q. Sun (2016). Food Chem.199, 356.

    Article  CAS  Google Scholar 

  20. J. Szymońska, M. Targosz-Korecka, and F. Krok (2009). J. Phys. Conf. Ser.146, 12027.

    Article  CAS  Google Scholar 

  21. C. Qiu, W. Wei, J. Sun, H.-T. Zhang, J.-S. Ding, J.-C. Wang, and Q. Zhang (2016). Nanoscale8, 13033.

    Article  CAS  Google Scholar 

  22. T. C. P. Dinis, V. M. C. Madeira, and L. M. Almeida (1994). Arch. Biochem. Biophys.315, 161.

    Article  CAS  Google Scholar 

  23. T. Hatano, H. Kagawa, T. Yasuhara, and T. Okuda (1988). Chem. Pharm. Bull. (Tokyo).36, 2090.

    Article  CAS  Google Scholar 

  24. S. K. Das, S. Behera, J. K. Patra, and H. Thatoi (2019). J. Clust. Sci.30, 1103.

    Article  CAS  Google Scholar 

  25. N. S. Podio, L. Bertrand, D. A. Wunderlin, and A. N. Santiago (2020). Chemosphere241, 125057.

    Article  CAS  Google Scholar 

  26. S. Bel Haaj, A. Magnin, C. Pétrier, and S. Boufi (2013). Carbohydr. Polym.92, 1625.

    CAS  Google Scholar 

  27. H. Park, S. Xu, and K. Seetharaman (2011). Carbohydr. Res.346, 847.

    Article  CAS  Google Scholar 

  28. C. S. de Oliveira, M. M. P. Andrade, T. A. D. Colman, F. J. O. G. da Costa, and E. Schnitzler (2014). J. Therm. Anal. Calorim.115, 13–18.

    Article  CAS  Google Scholar 

  29. T. Shahnaz, M. M. F. S., P. V.C., and S. Narayanasamy (2020). Int. J. Biol. Macromol.151, 322.

    Article  CAS  Google Scholar 

  30. L. E. Velásquez-Castillo, M. A. Leite, C. Ditchfield, P. J. do A. Sobral, and I. C. F. Moraes (2020). Int. J. Biol. Macromol.143, 93.

    Article  CAS  Google Scholar 

  31. E. Apostolidis and I. Mandala (2020). Food Hydrocoll.103, 105677.

    Article  CAS  Google Scholar 

  32. J. Saeng-on and D. Aht-Ong (2017). Polym. from Renew. Resour.8, 91.

    Google Scholar 

  33. B. M. Ibrahim and N. A. Fakhre (2019). Int. J. Biol. Macromol.123, 70.

    Article  CAS  Google Scholar 

  34. M. R. Almeida, R. S. Alves, L. B. L. R. Nascimbem, R. Stephani, R. J. Poppi, and L. F. C. de Oliveira (2010). Anal. Bioanal. Chem.397, 2693.

    Article  CAS  Google Scholar 

  35. R. Sapkal, S. Shinde, K. Rajpure, and C. Bhosale (2013). J. Semicond. 34, 53001.

    Article  CAS  Google Scholar 

  36. K. Banerjee, G. Padmavathi, D. Bhattacherjee, S. Saha, A. B. Kunnumakkara, and K. P. Bhabak (2018). Org. Biomol. Chem. 16, 8769–8782.

    Article  CAS  Google Scholar 

  37. H. Bagur, C. C. Poojari, G. Melappa, R. Rangappa, N. Chandrasekhar, and P. Somu (2019). J. Clust. Sci. https://doi.org/10.1007/s10876-019-01731-4.

    Article  Google Scholar 

  38. C. Patra, R. M. N. Medisetti, K. Pakshirajan, and S. Narayanasamy (2019). Environ. Sci. Pollut. Res.26, 23625.

    Article  CAS  Google Scholar 

  39. T. Shahnaz, C. Patra, V. Sharma, and N. Selvaraju (2020). Chem. Ecol. 1. https://doi.org/10.1080/02757540.2020.1723560.

    Article  Google Scholar 

  40. S. Srivastava and Y. K. Sharma (2013). ISRN Toxicol. 1. https://doi.org/10.1155/2013/340925.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors acknowledge the financial assistance from Indian Institute of Technology Guwahati, India (Grant No. BSBESUGIITG01213xSEN001) to undertake the study. We highly appreciated the high-throughput instrumentation assistance of The Central Instrumentation Facility, Indian Institute of Technology Guwahati.

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Authors and Affiliations

  1. Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India

    V. Vishnu Priyan, Tasrin Shahnaz, Ajaikumar B. Kunnumakkara, Varsha Rana & Selvaraju Narayanasamy

  2. Department of Medical Microbiology and Immunology, Division of Biomedical Science, School of Medicine, College of Health Sciences Mekelle University, Mekelle, Ethiopia

    Muthupandian Saravanan

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  1. V. Vishnu Priyan
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  2. Tasrin Shahnaz
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Priyan, V.V., Shahnaz, T., Kunnumakkara, A.B. et al. Antioxidant, Anti-inflammatory and Biosorption Properties of Starch Nanocrystals In Vitro Study: Cytotoxic and Phytotoxic Evaluation. J Clust Sci 32, 1419–1430 (2021). https://doi.org/10.1007/s10876-020-01905-5

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